Friday, August 03, 2007

The Top 10 Worst Heredity Conditions



The Top 10 Worst Heredity Conditions
livescience.com

BALDNESS

Although baldness is common in men, scientists don't understand much about why so little is going on up there. Genes do play a role, but your mom is not the only one at fault. Baldness is likely due to abnormalities in several genes from one or both parents. People with a rare type of permanent baldness called alopecia universalis, lose hair all over their bodies and carry defective 'hairless' genes.

LACTOSE INTOLERANCE

The Chinese distaste for milk was thought to be a cultural one, until scientists in the 1960s discovered lactose intolerance in Asians, Africans, and southern Europeans. Within the past 10,000 years, a genetic change allowed the ability to digest milk to evolve, but only where dairy farming was the norm. If you can't tolerate milk, your relatives probably left cow udders alone.

ACNE

Go ahead and fault your parents for your pimples. Studies have shown that many school-age boys with acne have a family history of the skin condition. As well, having parents who endured a bad case of zits makes one more likely to suffer from severe acne too.

HAVING TWINS

Although identical twins are random events, fraternal twins pop up in families again and again. A mother doing double diaper duty carries a gene that makes her release multiple eggs during ovulation, called hyperovulation. Although a man who carries the gene will probably not father twins, passing the family trait to his daughter could make him a grandfather of twins. This is why twins sometimes appear to skip generations, even though there's no evidence that twins are more likely to occur every other generation.

HEART DISEASE

A family history of heart disease, diabetes, stroke or high blood pressure isn't good for your heart. Children of parents with heart and blood vessel diseases are more likely to develop them too. Plus, a person with a congenital heart defect is slightly more likely to have a baby with a heart defect.

OBESITY

Super size fries and a heavy set of genes is a recipe for obesity. One scientific theory suggests the same genes that helped our ancestors survive famines are now working against people living in places where food is plentiful. Genes have been shown to be the cause of obesity disorders such as Bardet-Biedl syndrome and Prader-Willi syndrome. Many of today's bulging waistlines have only to do with eating too much of the wrong foods, however.

BULLYING

Next time you're in the principal's office with a pink slip for roughhousing on the playground, point the finger at your family. A gene that increases an individual's risk for violence has been discovered. Researchers have also found aggressive behaviors in boys are more likely to be inherited than non-aggressive antisocial behaviors like stealing someone's lunchbox. But genes play a bigger role in female thieves.

COLOR BLINDNESS

Ten million men in the U.S. cannot distinguish red from green. Yet the disorder only affects less than 600,000 American women. Why? The genes for red and green receptors sit near each other on the X-chromosome. Men only have one X-chromosome, which they inherit from their mother. Meanwhile, women have two, and a normal gene can often balance out a defective one.

BREAST CANCER

The cause of most breast cancers is still a mystery, however researches have discovered that mutations in particular genes, such as BRCA1 and BRCA2, cause some cancers. Women who inherit the mutation tend to get cancer early in life and in both breasts. Men with BRCA1 have an increased risk of prostate cancer, while BRCA2 increases the likelihood of cancers in the male breast, prostate, pancreas, and elsewhere.

ALCOHOLIM

Children of alcoholics are not destined to be alcoholics too. But recent research reports about 50 percent of the risk for alcoholism is genetically determined. The environment accounts for the other risky half. The disease is considered genetically complex, meaning that several genes come into play and they can affect individuals differently.

Top 10 Aphrodisiacs




Top 10 Aphrodisiacs
livescience.com

Rhino Horn

It's sad how our effort to promote the survival of our species through copious copulation has run other species to the brink of extinction. Rhino horn, prized by some as an alleged aphrodisiac, offers no such sexual power; and its (illegal) use in Chinese medicine for other ailments is questionable. The horns look a little like an erect penis, and in traditional medicine that's sometimes enough to mean that grinding them up and eating them will make one's own penis erect. At best, they contain nutrients, such as phosphorus, which gave our nutrient-poor ancestors a little more energy.

Spanish Fly

Not a fly and not strictly from Spain. That basically sums up the lies behind this potentially deadly aphrodisiac. Spanish Fly is ground-up blister beetle, indigenous to Europe. The beetle contains a caustic acid-like juice called cantharidin. When this stuff is ingested and eventually excreted, it causes a burning and swelling sensation in the urinary tract misconstrued as sexual stimulation. The only problem is that cantharidin is toxic, and the victims are usually women who unwittingly consume the powder in a drink. Most Spanish Fly sold today is just pepper or something to make you feel hot.

Alcohol

Alcohol, a false aphrodisiac, merely lowers inhibitions and raises the level of one's irrationality. Even worse, booze and other party drugs such as cocaine and ecstasy (MDMA) contribute to erectile dysfunction, according to Karen Boyle, director of Reproductive Medicine and Surgery unit at Johns Hopkins Hospital in Baltimore: "These drugs effect blood flow by their actions on arteries and veins and [negatively] impact testosterone levels, and thus libido." A few drinks are fine, but relying on alcohol to get in the mood could be a sign of a deeper problem.

Chocolate

Nope, but so what. Chocolate has phenylethylamine and serotonin, two chemicals that light up pleasure areas in the brain. Chocolate is similar to sex in that it makes you feel good. This doesn't imply, and no studies have shown that chocolate increases sexual desire. Hershey's Kisses might lead to kisses, but the passion was likely firmly in place beforehand.

Oysters

Many foods (bananas, asparagus, carrots, avocados) are considered aphrodisiacs because they resemble the penis or testicles. Oysters resemble a vagina. The Romans placed the oyster high on their list of prized aphrodisiacs. Casanova, the legend goes, would eat 50 raw oysters for breakfast. Yet interestingly, oysters (and pine nuts, another ancient aphrodisiac) are high in zinc, which is necessary for sperm production. Raw oysters are also high in D-aspartic acid and N-methyl-D-aspartate, which increased testosterone levels in one study on male rats, which could in theory increase libido, according to Karen Boyle of Johns Hopkins Hospital. "The data is questionable and mixed, but oysters do make a nice appetizer," she said.

Yohimbe, Tribulus and Maca

There are several traditional herbs under study for their aphrodisiac properties, and three leading contenders are yohimbe, tribulus and maca. Any combination of these might be pulverized, capsulated and sold as "natural Viagra." Most level-headed researchers, however, will warn you to stay away from this kind of stuff. Too much yohimbe, a bark from a West African evergreen tree, can kill you, which is not the kind of stiffness most guys are after. You never know what you're getting when you buy so-called natural cures. Many drugs come from plants; aspirin was isolated from willow bark. So yohimbe and the like are being studied to see if there are medicinal properties that can be isolated and turned into a reliable treatment for sexual dysfunction.

Viagra

There's a reason why "natural Viagra" ads clog your email inbox. Viagra works, and scheisters are trying to cash in Pfizer's billion-dollar success story. Viagra is not an aphrodisiac, per se. One needs sexual stimulation for the drug to work. (Your heightened sexual desire is likely in place, making you buy Viagra.) Before the dawn of Viagra and similar prescription drugs about a decade ago, urologists had little success in treating erectile dysfunction with medication. Viagra increases blood flow to the penis and blocks the blood from leaving, helping men maintain an erection. There are side effects, some serious, for a small percentage of users, but guys don't seem to care.

Psychoanalysis

Sometimes sexual dysfunction in men and women is a result of depression, fatigue or psychological disorder. Psychiatrists, counselors and sex therapists can often serve as a powerful aphrodisiac to enhance your libido. Psychoanalysis: sounds sexy, doesn't it?

Getting In Shape

As reported by Johns Hopkins researchers two weeks ago in the American Journal of Medicine, erectile dysfunction is highly correlated with poor physical health and inactivity. More than 50 percent of subjects with diabetes and 44 percent of those with high blood pressure had trouble achieving an erection either "sometimes" or "always." Ditto for the 26 percent of subjects who reported such sedentary behavior as watching three or more hours of television per day. Those who are fit tend to have more self-confidence, too. "Being in shape, eating healthfully, not smoking and not drinking are all ways to prevent obesity, diabetes, hypertension, kidney disease, peripheral vascular disease and hypercholesterolemia - - things that significantly impact blood flow," said Dr. Karen Boyle of Johns Hopkins Hospital. "I counsel all of my patients about making these lifestyle changes for 'penile health.'"

Respect

Dr. Ruth often speaks of respecting your sex partner and understanding his or her needs. Sex need not be centered on vaginal penetration and male ejaculation. There are a variety ways to please your partner sexually. And the most meaningful sexual relationships begin with respect. Try it with your lover. It can be a real turn-on.

10 Things About You



10 Things You Didn't Know About You
livescience.com

10 Your Stomach Secretes Corrosive Acid
There's one dangerous liquid no airport security can confiscate from you: It's in your gut. Your stomach cells secrete hydrochloric acid, a corrosive compound used to treat metals in the industrial world. It can pickle steel, but mucous lining the stomach wall keeps this poisonous liquid safely in the digestive system, breaking down lunch.

9 Body Position Affects Your Memory
Can't remember your anniversary, hubby? Try getting down on one knee. Memories are highly embodied in our senses. A scent or sound may evoke a distant episode from one's childhood. The connections can be obvious (a bicycle bell makes you remember your old paper route) or inscrutable. A recent study helps decipher some of this embodiment. An article in the January 2007 issue of Cognition reports that episodes from your past are remembered faster and better while in a body position similar to the pose struck during the event.

8 Bones Break (Down) to Balance Minerals
In addition to supporting the bag of organs and muscles that is our body, bones help regulate our calcium levels. Bones contain both phosphorus and calcium, the latter of which is needed by muscles and nerves. If the element is in short supply, certain hormones will cause bones to break down--upping calcium levels in the body--until the appropriate extracellular concentration is reached.

7 Much of a Meal is Food For Thought
Though it makes up only 2 percent of our total body weight, the brain demands 20 percent of the body's oxygen and calories. To keep our noggin well-stocked with resources, three major cerebral arteries are constantly pumping in oxygen. A blockage or break in one of them starves brain cells of the energy they require to function, impairing the functions controlled by that region. This is a stroke.

6 Thousands of Eggs Unused by Ovaries
When a woman reaches her late 40s or early 50s, the monthly menstrual cycle that controls her hormone levels and readies ova for insemination ceases. Her ovaries have been producing less and less estrogen, inciting physical and emotional changes across her body. Her underdeveloped egg follicles begin to fail to release ova as regularly as before. The average adolescent girl has 34,000 underdeveloped egg follicles, although only 350 or so mature during her life (at the rate of about one per month). The unused egg follicles then deteriorate. With no potential pregnancy on the horizon, the brain can stop managing the release of ova.

5 Puberty Reshapes Brain Structure, Makes for Missed Curfews
We know that hormone-fueled changes in the body are necessary to encourage growth and ready the body for reproduction. But why is adolescence so emotionally unpleasant? Hormones like testosterone actually influence the development of neurons in the brain, and the changes made to brain structure have many behavioral consequences. Expect emotional awkwardness, apathy and poor decision-making skills as regions in the frontal cortex mature.

4 Cell Hairs Move Mucus
Most cells in our bodies sport hair-like organelles called cilia that help out with a variety of functions, from digestion to hearing. In the nose, cilia help to drain mucus from the naval cavity down to the throat. Cold weather slows down the draining process, causing a mucus backup that can leave you with snotty sleeves. Swollen nasal membranes or condensation can also cause a stuffed schnozzle.

3 Big Brains Cause Cramped Mouths
Evolution isn't perfect. If it were, we might have wings instead of wisdom teeth. Sometimes useless features stick around in a species simply because they're not doing much harm. But wisdom teeth weren't always a cash crop for oral surgeons. Long ago, they served as a useful third set of meat-mashing molars. But as our brains grew our jawbone structure changed, leaving us with expensively overcrowded mouths.

2 The World Laughs with You
Just as watching someone yawn can induce the behavior in yourself, recent evidence suggests that laughter is a social cue for mimicry. Hearing a laugh actually stimulates the brain region associated with facial movements. Mimicry plays an important role in social interaction. Cues like sneezing, laughing, crying and yawning may be ways of creating strong social bonds within a group.

1 Your Skin Has Four Colors
All skin, without coloring, would appear creamy white. Near-surface blood vessels add a blush of red. A yellow pigment also tints the canvas. Lastly, sepia-toned melanin, created in response to ultraviolet rays, appears black in large amounts. These four hues mix in different proportions to create the skin colors of all the peoples of Earth.

Top 10 Ancient Capitals

livescience.com
Top 10 Ancient Capitals

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Photo Credit: Cahokia Mounds State Historic Park, courtesy of State of Illinois, NPS photo

Cahokia

With upwards of 30,000 inhabitants at its peak in about 1100 AD, Cahokia, Illinois remained North America's first and biggest real city until the Northeast's population exploded in the late 18th century. This urban center of the Mississippi culture had organized leadership, commerce and a penchant for mound-building. Monk's Mound, the largest at 100 feet tall, dominates the site and was probably a mighty foundation for the home of the resident spiritual leader.


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Photo Credit: Terracotta Warriors inside the Qin Shi Huang Mausoleum, 3rd century BC.

Xi'an

The Chinese city of Xi'an was the central stronghold for all of the country's most important ancient dynasties going back 3,000 years. Tourists flocking to see the city's Terra Cotta Army, 6,000 unique and life-size statues buried to protect the tomb of the great Zhou emperor Qin Shi Huang, has made Xi'an famous in modern times. That will only multiply when the emperor's sprawling mausoleum, rumored to hold invaluable treasures and rivers of mercury, is finally opened by archaeologists.


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Photo Credit: Jan Derk

Great Zimbabwe

At 1,800 acres in breadth and the only one of its kind in Africa, the complex of Great Zimbabwe confounded early European colonialists, who couldn't believe that sub-Saharan peoples were capable of its creation. They were, in fact, and built the complicated structures sometime after 1200 AD, when a wide-reaching empire of about 20,000 Shona cattlemen ruled the area.


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Photo Credit: Stockxpert

Thebes

Most people think of Cairo and the Great Pyramids when they think of ancient Egypt, but the heartbeat of the magical pharaonic dynasties actually beat much further up the Nile at Thebes. Thebes was the ruling capital of ancient Egypt during its most dominant eras, beginning with the Old Kingdom 4500 years ago, and is home to two of its most revered temples at Karnak and Luxor. Most of Egypt's holy rulers are also buried nearby in the famous Valley of the Kings.


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Photo Credit: Tenochtitlan, looking east. From the mural painting at the National Museum of Anthropology, Mexico City. Painted in 1930 by Dr Atl.

Tenochtitlan

Legend--and bits and pieces of historical fact--indicates that Tenochtitlan was once the world's biggest and most beautiful city. The capital of the great Aztec empire, which eventually morphed into today's Mexico City, had about 300,000 inhabitants when Spanish conquistadors arrived in 1521. Despite being built atop a lake according to the wishes of an important Aztec deity, ancient engineers made Tenochtitlan as efficient as any city in Europe with a complex system of causeways and canals.


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Photo Credit: Stockxpert

Cuzco

All roads in the Incan empire once lead to Cuzco, bustling capital in the Andes Mountains from the early 1400s until its discovery by European explorers in 1532. To retreat from the big city, Incan kings would head to their summer home of Machu Picchu further up in the mountains.


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Photo Credit: A 16th century depiction of the Hanging Gardens of Babylon (by Martin Heemskerck)

Babylon

Famous for its "wondrous" hanging gardens, the ancient Mesopotamian city of Babylon had as turbulent a history as its location in present-day Iraq suggests. Everyone from the ancient Assyrians to Alexander the Great wanted to get their hands on this strategic location, and it would become the capital for many ruling groups over a period of several thousand years. King Nebuchadnezzar II, creator of the gardens, led the city during its splendid architectural heyday around 600 BC.



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Photo Credit: Stockxpert

Constantinople

Today it's shared by two continents as the Turkish city of Istanbul, but ancient Constantinople never once had to share the spotlight after Rome fell from grace in the 4th century AD. From that date through the Middle Ages, Constantinople was the world's largest and richest city, becoming the center of the new Roman Empire, the Byzantine Empire and finally the Ottoman Empire. Art and learning flourished in its universities and cathedrals, including the spectacular Hagia Sophia.



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Photo Credit: Kevin T. Glowacki and Nancy L. Klein

Athens

Democracy, math, philosophy, the Olympics...what didn't come out of Athens, the ethereal capital of ancient Greece? Athens fought long and hard, in conflicts on the sea and on land, to become leader of all Aegean city-states by the early 5th century BC. It celebrated its victories by building great temples like the Parthenon, the iconic symbol of art and architecture in ancient Greece. A plague--likely typhoid fever--contributed to the empire's fall.

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Photo Credit: Heather Whipps

Rome

It's impossible to stroll through modern Rome and not bump into reminders of its ancient past. The Forum, the Colosseum and the Pantheon, just to name a few, are lasting testaments to the capital of an empire once made up of 2.5 million square miles, three continents and about 100 million people. The empire reached its zenith in 117 AD, when the emperor Trajan ruled from Rome and months-long gladiator games were held to celebrate the city's glory.

Patients Suffer Dejà Vu ... Over and Over



Patients Suffer Dejà Vu ... Over and Over
By Robert Roy Britt, LiveScience Managing Editor
posted: 30 January 2006 01:34 pm ET


Imagine suffering from chronic dejà vu. You don't even go to the doctor because you feel like you've already been there.
"We had a peculiar referral from a man who said there was no point visiting the clinic because he'd already been there, although this would have been impossible," said psychologist Chris Moulin, who runs a memory clinic at the University of Leeds in the UK.
So Moulin has started the first known study of the condition.
Dejà vu hits most of us now and then. We're struck by the sensation that we have experienced an event before, even though we can't fully remember it or perhaps know it didn't really happen. The sensation is fleeting, so researchers can't study it.
But Moulin figures chronic dejà vu sufferers offer an opportunity to do research that might unlock the secrets of the everyday variety.
The man who thinks he's been to Moulin's clinic even gave details of the visit that never occurred. He has dejà vu so bad that he doesn't watch TV news because he feels like he's seen it all before, Moulin said. Things get tricky when the man is asked to predict what's ahead, however.
"When this particular patient's wife asked what was going to happen next on a TV program he'd claimed to have already seen, he said, 'How should I know? I have a memory problem!'"
Moulin and colleagues have since found other patients, now that they know what to look for.
The condition can cause depression and is sometimes diagnosed as a state of delusion. But Moulin's team believes it to be a dysfunction of memory.
"The exciting thing about these people is that they can 'recall' specific details about an event or meeting that never actually occurred," Moulin said. "It suggests that the sensations associated with remembering are separate to the contents of memory, that there are two different systems in the brain at work."
The problem might involve a memory circuit that is overactive or stuck in the "on" position.
The researchers plan now to use brain scans in an effort to pinpoint the problem.





What Causes Déjà Vu?
Sunday September 10, 2006

That distinct illusion of having been there and done that has no explanation. The parapsychologist will tell you it's a past life experience. Yogi Berra will remind you it seems like you've felt it before. And most scientists will throw their hands up. Some believe déjà vu involves emotional responses to similar events; others figure the brain short circuits, sending an event to memory just a split second before putting it into consciousness.

Its fleeting nature makes déjà vu about as easy to study as the afterlife. Some people have a chronic variety, though, and so one study is attempting to get inside their minds. Chris Moulin, who runs a memory clinic at the University of Leeds in the UK and is doing the research, describes one patient who illustrates how déjà vu might be related to memories being mixed up by the brain: "When this particular patient's wife asked what was going to happen next on a TV program he'd claimed to have already seen, he said, 'How should I know? I have a memory problem!'"

Top 10 Mysteries of the Mind




Top 10 Mysteries of the Mind

10 DREAMS
If you were to ask 10 people what dreams are made of, you'd probably get 10 different answers. That's because scientists are still unraveling this mystery. One possibility: Dreaming exercises brain by stimulating the trafficking of synapses between brain cells. Another theory is that people dream about tasks and emotions that they didn't take care of during the day, and that the process can help solidify thoughts and memories. In general, scientists agree that dreaming happens during your deepest sleep, called Rapid Eye Movement (REM).

9 REM SLEEP
Fruit flies do it. Tigers do it. And humans can't seem to get enough of it. No, not that. We're talking about shut-eye, so crucial we spend more than a quarter of our lives at it. Yet the underlying reasons for sleep remain as puzzling as a rambling dream. One thing scientists do know: Sleep is crucial for survival in mammals. Extended sleeplessness can lead to mood swings, hallucination, and in extreme cases, death. There are two states of sleep--non-rapid eye movement (NREM), during which the brain exhibits low metabolic activity, and rapid eye movement (REM), during which the brain is very active. Some scientists think NREM sleep gives your body a break, and in turn conserves energy, similar to hibernation. REM sleep could help to organize memories. However, this idea isn't proven, and dreams during REM sleep don't always correlate with memories.


8 PHANTOM FEELINGS
It's estimated that about 80 percent of amputees experience sensations, including warmth, itching, pressure and pain, coming from the missing limb. People who experience this phenomenon, known as "phantom limb," feel sensations as if the missing limb were part of their bodies. One explanation says that the nerves area where the limb severed create new connections to the spinal cord and continue to send signals to the brain as if the missing limb was still there. Another possibility is that the brain is "hard-wired" to operate as if the body were fully intact--meaning the brain holds a blueprint of the body with all parts attached.


7 BIOLOGICAL CLOCK
Residing in the hypothalamus of the brain, the suprachiasmatic nucleus, or biological clock, programs the body to follow a 24-hour rhythm. The most evident effect of circadian rhythm is the sleep-wake cycle, but the biological clock also impacts digestion, body temperature, blood pressure, and hormone production. Researchers have found that light intensity can adjust the clock forward or backward by regulating the hormone melatonin. The latest debate is whether or not melatonin supplements could help prevent jet lag--the drowsy, achy feeling you get when "jetting" across time zones.


6 MEMORY
Some experiences are hard to forget, like perhaps your first kiss. But how does a person hold onto these personal movies? Using brain-imaging techniques, scientists are unraveling the mechanism responsible for creating and storing memories. They are finding that the hippocampus, within the brain's gray matter, could act as a memory box. But this storage area isn't so discriminatory. It turns out that both true and false memories activate similar brain regions. To pull out the real memory, some researchers ask a subject to recall the memory in context, something that's much more difficult when the event didn't actually occur.

5 LAUGHTER
Laughter is one of the least understood of human behaviors. Scientists have found that during a good laugh three parts of the brain light up: a thinking part that helps you get the joke, a movement area that tells your muscles to move, and an emotional region that elicits the "giddy" feeling. But it remains unknown why one person laughs at your brother's foolish jokes while another chuckles while watching a horror movie. John Morreall, who is a pioneer of humor research at the College of William and Mary, has found that laughter is a playful response to incongruities--stories that disobey conventional expectations. Others in the humor field point to laughter as a way of signaling to another person that this action is meant "in fun." One thing is clear: Laughter makes us feel better.


4 NATURE V. NURTURE
In the long-running battle of whether our thoughts and personalities are controlled by genes or environment, scientists are building a convincing body of evidence that it could be either or both! The ability to study individual genes points to many human traits that we have little control over, yet in many realms, peer pressure or upbringing has been shown heavily influence who we are and what we do.


3 AGING
Living forever is just for Hollywood. But why do humans age? You are born with a robust toolbox full of mechanisms to fight disease and injury, which you might think should arm you against stiff joints and other ailments. But as we age, the body's repair mechanisms get out of shape. In effect, your resilience to physical injury and stress declines. Theories for why people age can be divided into two categories: 1) Like other human characteristics, aging could just be a part of human genetics and is somehow beneficial. 2) In the less optimistic view, aging has no purpose and results from cellular damage that occurs over a person's lifetime. A handful of researchers, however, think science will ultimately delay aging at least long enough to double life spans.

2 DEATH
Living forever may not be a reality. But a pioneering field called cryonics could give some people two lives. Cryonics centers like Alcor Life Extension Foundation, in Arizona, store posthumous bodies in vats filled with liquid nitrogen at bone-chilling temperatures of minus 320 degrees Fahrenheit (78 Kelvin). The idea is that a person who dies from a presently incurable disease could be thawed and revived in the future when a cure has been found. The body of the late baseball legend Ted Williams is stored in one of Alcor's freezers. Like the other human popsicles, Williams is positioned head down. That way, if there were ever a leak in the tank, the brain would stay submerged in the cold liquid. Not one of the cryopreserved bodies has been revived, because that technology doesn't exist. For one, if the body isn't thawed at exactly the right temperature, the person's cells could turn to ice and blast into pieces.


1 CONSCIOUSNESS
When you wake up in the morning, you might perceive that the Sun is just rising, hear a few birds chirping, and maybe even feel a flash of happiness as the fresh morning air hits your face. In other words, you are conscious. This complex topic has plagued the scientific community since antiquity. Only recently have neuroscientists considered consciousness a realistic research topic. The greatest brainteaser in this field has been to explain how processes in the brain give rise to subjective experiences. So far, scientists have managed to develop a great list of questions.

Leonardo Da Vinci's 10 Best Ideas

livescience.com
Leonardo Da Vinci's 10 Best Ideas

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IMAGE CREDIT: By Permission of the British Library Arundel 263, f.4v,11


Mirror Writing

Was it a ploy to thwart Renaissance copycats peeking at his notes, or just a way to avoid the inky mess of writing left-handed? Whatever his motives, Da Vinci sure liked mirror writing: most of his journals are scrawled in reverse.


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IMAGE CREDIT: By Permission of the British Library Arundel 263, f.24v


Scuba Gear

Da Vinci's fascination with the sea spurred many designs for aquatic exploration. His diving suit was made of leather, connected to a snorkel made of cane and a bell that floated at the surface. Proving the artist was also practical, the suit included a pouch the diver could urinate in.


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IMAGE CREDIT: Courtesy of Museo Nazionale della Scienza e della Tecnologia Leonardo da Vinci


The Revolving Bridge

Always a fan of the quick getaway, Da Vinci thought his revolving bridge would be best used in warfare. The light yet sturdy materials, affixed to a rolling rope-and-pulley system, allowed an army to pick up and go at a moment's notice.


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IMAGE CREDIT: Courtesy of Museo Nazionale della Scienza e della Tecnologia Leonardo da Vinci


The Winged Glider

Da Vinci's imagination was filled to capacity with ideas for flying machines, including several gliders equipped with flappable wings. This open-shelled model, fitted with seats and gears for the pilot, did not include a design for a crash helmet.


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IMAGE CREDIT: Courtesy of Museo Nazionale della Scienza e della Tecnologia Leonardo da Vinci


The Triple-Barreled Cannon

More thinker than fighter, Da Vinci's distaste for conflict didn't stop him from dreaming up designs for more efficient cannons like this one. His jacked-up triple-barrel would have been a deadly weapon on the battlefield, fast and light with lots of extra fire power.


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IMAGE CREDIT: Courtesy of Museo Nazionale della Scienza e della Tecnologia Leonardo da Vinci


The Aerial Screw

Modern scientists agree it may never have lifted off the ground, but Da Vinci's "helicopter" design is still one of his most famous. The curious contraption was meant to be operated by a four-man team and could have been inspired by a windmill toy popular in Leonardo's time.


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IMAGE CREDIT: Courtesy of Museo Nazionale della Scienza e della Tecnologia Leonardo da Vinci


The Ideal City

Living in a Milan wrought with plague, Da Vinci envisioned a more efficient city he'd be proud to call home. His architectural draughts are highly detailed and even include horse stables with fresh air vents.


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IMAGE CREDIT: Courtesy of Museo Nazionale della Scienza e della Tecnologia Leonardo da Vinci


The Self-Propelled Car

It's no Ferrari, but Da Vinci's designs for a self-propelled vehicle were revolutionary for his day. His wooden "car" moved by the interaction of springs with geared wheels. Scientists at one museum in Florence built a replica in 2004 and found it worked as Da Vinci intended.


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IMAGE CREDIT: stock.xchng


Geologic Time

Plate tectonics? No sweat. While most of his contemporaries explained inland, mountain-top mollusk fossils as leftovers from the Great Flood, Da Vinci thought otherwise. He supposed (right) that the mountains must once have been coastline before many years of gradually shifting upwards.


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The Vitruvian Man

Da Vinci modeled his perfect human form after the proportions laid out by Vitruvius, an ancient Roman architect. The angry-looking man drawn by Da Vinci has reason to smile - he's now considered one of the most recognizable figures on earth.

Top 10 Battles for the Control of Iraq

Top 10 Battles for the Control of Iraq

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This fragment from the Stele of the Vultures, erected by Eannatum of Lagash, now at the Louvre Museum, Paris depicts the battle of Umma with Eannatum of Lagash defeating the king of Umma.

2525 BC - Battle between Lagash and Umma
By 3000 BC, the Sumerians had developed into the earliest civilization of Mesopotamia. The societies were organized into city-states, which warred constantly over the control of water. Two of these, Lagash and Umma, sat 18 miles apart and feuded for generations over the fertile region known as Gu'edena. In 2525, King Eannatum of Lagash defeated Umma using armored soldiers in phalanx formations, and also chariots pulled by onagers (wild asses), an invention frequently credited to the Sumerians. How do we know of this battle? It was recorded by the king on a stone monument, "the Stele of the Vultures."

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Sargon overthrew the Sumerian king at Nippur and established what became known as the first empire in human history, becoming the king of Akkad.


Around 2300 BC - Military campaigns of Sargon the Great

Sargon of Akkad may have been the world's first empire-builder. Legend states that he was found floating in a basket and brought up by a gardener. Later it is known he became a cupbearer to King Ur-Zazaba of Kish in Sumer. Sargon rose from obscurity to overthrow Lugalzaggisi of Uruk, famously forcing the defeated ruler into a yoke and leading him to the gate of Enlil, a god, at Nippur. Sargon also attacked 34 Sumerian cities. In the process, he tore down the walls of the vanquished, imprisoned 50 ensis (city-state rulers), and "cleaned his weapons in the sea" (Persian Gulf). Thus the Akkadian empire rose and the Mesopotamian military tradition was born.


8.

Shalmaneser I was the king of Assyria. He restored the temple at Assur, established a royal residence at Nineveh, and removed the capital from Assur to Calah, just south of Nineveh.


Around 1263 BC - Assyrian King Shalmaneser I defeated Shattuara II of Hanigalbat

Assyria developed around the city of Ashur on the upper Tigris, weaker than other states appearing after Hammurabi's dynasty, including the Kassites and the Hurrians/Mitanni. Assyria was long ruled by the Mitanni, but regained autonomy during the Middle Assyrian Empire. In his second year of rule, Shalmaneser I attacked the breakaway state of Uruatru in southern Armenia. Shattuara II of Hanigalbat, leading the rebellion with the aid of the Hittites, blockaded the mountain passes and waterholes. With a desperation born of thirst, the Assyrians pounded the Mitanni kingdom into submission. Afterwards, Shalmaneser claimed to have blinded 14,400 men, a nasty bit of psychological warfare. His inscriptions mention the utter devastation of nine fortified temples, 180 Hurrian cities, and the Hittite and Ahlamu armies. Obviously, the Assyrians were not well-liked.


7.

The last Persian Great King of the Achaemenid dynasty, Darius III Codomannus, is remembered in history for being defeated by Alexander the Great.


331 BC - Battle of Gaugamela

In 334 BC, Alexander III ("The Great") crossed the Hellespont (Dardanelles) with 7000 cavalrymen and over 30,000 infantrymen. During this expedition, Alexander defeated the king, Darius III, at the Battle of Issus. Darius retreated to the Plain of Gaugamela, near Arbela (Irbil). There he massed a enormous army and ordered the plain cleared for his scythed chariots and war elephants. Darius' army stood in a massive line. Alexander's outnumbered Macedonian forces attempted to draw the Persians away from the prepared ground. In countering, the Persian cavalry opened gaps in their own line, into which Alexander led his personal cavalry. The Persian chariots charged the Macedonians, which yielded and then decimated their drivers with projectiles. Alexander's elite cavalry turned and attacked from the rear. When Darius saw his troops in disarray, he fled, prompting a full retreat. Alexander had ended the Persian empire founded by Cyrus II.


6.

Marcus Licinius Crassus, a Roman businessman and politican, was infamous for ordering the mass crucifiction of more than 6000 of Spartacus' slave army along the Appian Way.


53 BC - Battle of Carrhae

Marcus Licinius Crassus became governor of Syria in 55 BC. A triumvir with Pompey and Julius Caesar, he sought to increase his reputation by invading Parthian Mesopotamia. With seven legions, about 44,000 men, he crossed the Euphrates. However, he strayed from the river into the open desert. Near Carrhae (Harran), the Parthians approached with 10,000 mounted archers. The Romans held a theoretical advantage, but lacked desert warfare experience (fighting at midday in June?), and staggered before the Parthian arrows, fired from compound bows. Also, the Parthian commander, General Suren, had thoughtfully brought 1000 camels to re-supply his archers with arrows. Surrounding the Romans, the Parthians turned the battle into dusty target practice. Only 10,000 Gauls were reported to survive. In attempting to surrender, Crassus was killed. Roman prestige plunged in the east.


5.

Once viewed as primitive and unorganized, the Arabs, united by Islam in the mid-600s AD soon conquered the Persian Empire.


637 AD - Battle of Al-Qadisiyah

The Persian Sasanians ruled Mesopotamia from 224 AD. They thrived for centuries, but eventually became distracted by fighting the Romans and amongst themselves. Ultimately, an unlikely outside force would topple them. The Arabs had been tribesmen, unorganized and militarily primitive. The new religion of Islam, founded by Muhammad, united the tribes. In 634, the Arab campaign against the Sassanians began. 18,000 Arab tribesmen, led by General Khalid ibn al Walid ("The Sword of Islam") reached the Euphrates delta and began battling the Iranians (Persians), who were rallied by their hero, Rustam. A decisive battle occurred at Al-Qidisiyah, a village south of Baghdad. Though outnumbered six to one, the Arabs defeated the Iranians, exhausted by many battles against the Byzantines. Rustam was killed. The Arabs shortly captured the Sassanid capital at Ctesiphon, ending their dynasty and introducing Islam to the region.


4.

16th Century representation of Hulagu Khan's seige of the Fort at Alamut in Iran. Hulagu, Ghengis Khan's grandson, conquered much of Southwest Asian, including what are now modern day Iraq and Iran.


1258 AD - Mongols besiege Baghdad

Mesopotamia had become known as "Iraq," the center of a large Muslim caliphate. The Abbasid ruling family established a new capital at Baghdad, which prospered. Early in the 13th Century AD, the Mongol leader, Temujin, organized the Mongol tribes into a marauding army over 700,000 strong, and began conquests of China, Persia, and Eastern Europe. He renamed himself Chinggis (Genghis) Khan ("World Conquerer"). A generation later, his grandson, Hulagu, was dispatched to capture the remainder of southwest Asia. In 1258, Hulagu besieged Baghdad, then sacked most of it, slaughtering as many as 800,000 of the inhabitants. He killed the scholars, erecting a pyramid of their skulls, and executed the caliph, al-Musta'sim, the 37th and final Abbisid ruler of a line that had lasted 500 years. Iraq was reduced to tribal culture, never to regain world prominence.


3.

During his reign, Suleyman the Magnificent, led the Ottoman Empire into its golden age, making it one of the world's cultural, political and military leaders.


1534 AD - Capture of Baghdad by Suleyman the Magnificent

In the early 1500's, the Ottomans began their rise to power as the next great Islamic state. The first ruler was Sultan Selim I ("The Grim"). His victory in 1514 at the Battle of Chaldiran over the Safavids of Iran paved the way for Ottoman expansion into northern Iraq, as the Safavids had conquered Iraq in 1509. Son of Selim, Suleyman I ("the Magnificent") succeeded to the throne in 1520, and by 1522 turned his attention to the Safavids, first negotiating a truce with Archduke Ferdinand of Hungary, leaving himself free to wage the first of three major campaigns against Persia. In 1534, he took the cities of Baghdad and most of Iraq from the Persians, an enormous success, leading to almost four centuries of Ottoman rule in Iraq.


2.

Ctesiphon is an ancient city on the Tigris, founded by the Parthians. It was here that British troops first engaged Turkish forces before Kut-al-Amara.


1915 AD - Siege of Kut-al-Amara

In World War I, England realized it must protect its Iraqi oil production interests against the German-Turkish alliance. In 1914, British forces began the Mesopotamian campaign at Al Faw. After several easy victories, an attempt on Baghdad was launched. However, the Anglo-Indian forces, commanded by Sir Charles Townshend, were undermanned and their supplies overstretched. In November, 1915, the British approached the ruins of Ctesiphon, on the Tigris 20 miles SE of modern Baghdad. The Turks, under Nur-ud-Din, had positioned about 18,000 experienced men in two trenches on either side of the river. The better-prepared Turks fended off the British, who dragged themselves back to occupied Kut-al-Amara. The Turks besieged the city for 143 days, ultimately forcing a British surrender. 10,000 men went into brutal captivity. The following year, the British finally took Baghdad, but the Siege of Kut-al-Amara was the army's greatest military defeat.


1.

Will McDermott from Phoenix, Az., provides security as Marines from the 1st Battalion 5th Marines break down a door while searching buildings for weapons in Fallujah, Iraq, Monday, April 19, 2004. (AP Photo/John Moore)


2003 AD - Operation Iraqi Freedom

Saddam Hussein's presidency of Iraq included a failed invasion of Kuwait in 1990 that precipitated the Persian Gulf War. Following the war, US officials suspected Iraq of cease-fire violations, including the production of weapons of mass destruction (WMD). In dealing with United Nation arms inspectors, Hussein proved intractable for more than 12 years. On March 20, 2003, a combined military force consisting of 300,000 primarily US and British troops entered Iraq through Kuwait. The reported pretext for the invasion was to locate and destroy chemical, nuclear, and biological WMDs, and depose Hussein. To date, no WMDs have been found. Baghdad fell on April 9. President George W. Bush declared the end of major combat operations on May 1, however, coalition forces remain to stabilize the country, experiencing frequent insurgent attacks. On December 13, Hussein was captured near his home town of Tikrit. Coalition fighters continue to encounter fierce resistance. By May 10, 2007, more than 3382 American and coalition troops had died in Iraq with the civilian casualties estimated at about 62,570.

Top 50 Reasons Men and Women Have Sex




Top 50 Reasons Men and Women Have Sex

By LiveScience Staff

posted: 31 July 2007 12:30 pm ET


A survey, detailed in the August issue of the journal Archives of Sexual Behavior, reveals what motivates a person to have sex. In all, the researchers found 237 reasons. Here are the top 50, first for women and then for men.

Top 50 reasons WOMEN have sex:

1. I was attracted to the person.

2. I wanted to experience the physical pleasure.

3. It feels good.

4. I wanted to show my affection to the person.

5. I wanted to express my love for the person.

6. I was sexually aroused and wanted the release.

7. I was "horny."

8. It’s fun.

9. I realized I was in love.

10. I was "in the heat of the moment."

11. I wanted to please my partner.

12. I desired emotional closeness (i.e., intimacy).

13. I wanted the pure pleasure.

14. I wanted to achieve an orgasm.

15. It’s exciting, adventurous.

16. I wanted to feel connected to the person.

17. The person’s physical appearance turned me on.

18. It was a romantic setting.

19. The person really desired me.

20. The person made me feel sexy.

21. The person caressed me.

22. It seemed like the natural next step in my relationship.

23. I wanted to become one with another person.

24. It just happened.

25. I wanted to increase the emotional bond by having sex.

26. I wanted the experience.

27. I wanted the adventure/excitement.

28. The person had an attractive face.

29. The person was a good kisser.

30. I wanted to intensify my relationship.

31. My hormones were out of control.

32. I wanted to try out new sexual techniques or positions.

33. I wanted to feel loved.

34. The person had a desirable body.

35. I wanted to celebrate a birthday or anniversary or special occasion.

36. I wanted to communicate at a "deeper" level.

37. I was curious about sex.

38. It was a special occasion.

39. The person was intelligent.

40. I wanted to say "I’ve missed you."

41. I wanted to keep my partner satisfied.

42. I got "carried away."

43. The opportunity presented itself.

44. The person had a great sense of humor.

45. I wanted to improve my sexual skills.

46. I was curious about my sexual abilities.

47. The person seemed self-confident.

48. I wanted to make up after a fight.

49. I was drunk.

50. I was turned on by the sexual conversation.


Top 50 reasons MEN have sex:

1. I was attracted to the person.

2. It feels good.

3. I wanted to experience the physical pleasure.

4. It’s fun.

5. I wanted to show my affection to the person.

6. I was sexually aroused and wanted the release.

7. I was "horny."

8. I wanted to express my love for the person.

9. I wanted to achieve an orgasm.

10. I wanted to please my partner.

11. The person’s physical appearance turned me on.

12. I wanted the pure pleasure.

13. I was "in the heat of the moment."

14. I desired emotional closeness (i.e., intimacy).

15. It’s exciting, adventurous.

16. The person had a desirable body.

17. I realized I was in love.

18. The person had an attractive face.

19. The person really desired me.

20. I wanted the adventure/excitement.

21. I wanted to feel connected to the person.

22. I wanted the experience.

23. It was a romantic setting.

24. The person caressed me.

25. The person made me feel sexy.

26. It seemed like the natural next step in my relationship.

27. I wanted to increase the emotional bond by having sex

28. I wanted to keep my partner satisfied.

29. The opportunity presented itself.

30. It just happened.

31. I wanted to intensify my relationship.

32. I wanted to try out new sexual techniques or positions.

33. My hormones were out of control.

34. The person was too "hot" (sexy) to resist.

35. I was curious about my sexual abilities.

36. I wanted to improve my sexual skills.

37. I wanted to become one with another person.

38. I saw the person naked and could not resist.

39. The person was a good kisser.

40. I wanted to feel loved.

41. I wanted to celebrate a birthday or anniversary or special occasion.

42. The person was too physically attractive to resist.

43. It was a special occasion.

44. I hadn’t had sex for a while.

45. The person had beautiful eyes.

46. I wanted to communicate at a "deeper" level.

47. I wanted to experiment with new experiences.

48. The person was intelligent.

49. I wanted to keep my partner happy.

50. I was curious about what the person was like in bed.

* Why We Have Sex: 237 Reasons Revealed

Brain electrodes help man speak again


An undated X-Ray image of a patient with Deep Brain Stimulation (DBS) leads implanted. A man with severe brain injuries who spent six years in a near-vegetative state can now chew his food, watch a movie and talk with family thanks to a brain pacemaker that may change the way such patients are treated, U.S. researchers said on Wednesday. (Cleveland Clinic/Handout/Reuters)


Brain electrodes help man speak again

By MALCOLM RITTER, AP Science WriterWed Aug 1, 2:53 PM ET

He was beaten and left for dead one night in a robbery while walking home in 1999. His skull was crushed and his brain severely damaged. The doctor said if he pulled through at all, he'd be a vegetable for the rest of his life.
For six years, the man could not speak or eat.
On occasion he showed signs of awareness, and he moved his eyes or a thumb to communicate. His arms were useless. He was fed through a tube.
But researchers chose him for an experimental attempt to rev up his brain by placing electrodes in it. And here's how his mother describes the change in her son, now 38:
"My son can now eat, speak, watch a movie without falling asleep," she said Wednesday while choking back tears during a telephone news conference. "He can drink from a cup. He can express pain. He can cry and he can laugh.
"The most important part is he can say, `Mommy' and `Pop.' He can say, `I love you, Mommy' ... I still cry every time I see my son, but it's tears of joy."
The progress of the patient, who remains unidentified at the family's request, is described more formally in a report in Thursday's issue of the journal Nature.
Experts called the results encouraging but cautioned that the experimental treatment must be tried in more patients before its value can be assessed. The researchers are already proceeding with a larger study.
Before the electrodes were implanted, the man was in what doctors call a "minimally conscious state." That means he showed only occasional awareness of himself and his environment. In a coma or vegetative state, by contrast, patients show no outward signs of awareness.
There are no reliable statistics on how many Americans are in a minimally conscious state, but one estimate suggests 112,000 to 280,000. Doctors may try medications to improve their condition but no drugs have been firmly established as helpful.
The experimental treatment is called deep brain stimulation. It has been used for years in treating Parkinson's disease, although in this case the electrodes were implanted in slightly different places. The goal of the stimulation was to provide "drive" to areas of the brain that are critical for specific skills like speaking.
Similar stories of partial recovery from brain damage occasionally grab headlines, whether the improvement came from treatment or just out of the blue.
Terry Wallis of Arkansas lingered in a minimally conscious state for almost 20 years before he suddenly regained some ability to speak and move in 2003. In 2005, a former firefighter in Buffalo, N.Y., turned from being barely aware and almost mute for nearly a decade into a virtual chatterbox for 14 hours. His doctor had been trying a cocktail of drugs.
The man described in the Nature paper, despite his improvements, remains severely disabled in a rehabilitation facility for brain injury on the East Coast. (To preserve the man's anonymity, the researchers would not identify the facility or even reveal which state it is in).
He can't walk. While he has regained the ability to chew and swallow, he must be spoon-fed. He can demonstrate the motion of brushing his teeth, for example, but he can't actually do it. That's because tendons in his arms contracted after years of immobility, said study lead author Dr. Nicholas Schiff of Weill Cornell Medical College in New York.
The man doesn't initiate conversation but can reply to others, generally with one to three words, said Dr. Joseph Giacino, a co-lead author of the Nature study.
Several weeks ago, he recited the first half of the Pledge of Allegiance without assistance, said Giacino, of the JFK Johnson Rehabilitation Institute in Edison, N.J.
The man's electrodes are left on for 12 hours a day. He has continued to improve since the experiment formally ended in February 2006, the doctors said.
After the research was over, doctors started giving him the drug amantadine, which has shown some potential for treating people in a minimally conscious state. It's not clear whether amantadine can boost the effects of deep brain stimulation or vice versa, Giacino said.
Dr. James Bernat, a professor of neurology at Dartmouth Medical School who didn't participate in the new research, called the Nature report exciting and important. Further study is needed to sort out how many patients would respond and how to identify the minimally conscious patients with the best chance of being helped, he said.
He noted that a similar treatment did not help Terri Schiavo, the Florida woman in a vegetative state whose care triggered national controversy before her death in 2005. That's the typical outcome for electrical brain stimulation in vegetative states, he said.
Dr. Ross Zafonte of the University of Pittsburgh, who also was familiar with the study results, agreed that "we need to know more." He said the approach is "very interesting and holds great promise."
___
On the Net:
http://www.nature.com/nature

Anders Sandberg wants to emulate your brain




Anders Sandberg wants to emulate your brain


George Dvorsky
Sentient Developments

2007-08-01

Transhumanists have long speculated about the possibility of uploading a brain into a computer. In fact, a big part of the supposed posthuman future depends on it.
Soooo, how the hell do we do it?
This is the issue that Swedish neuroscientist Anders Sandberg tackled for his talk at TransVision 2007. Uploading, or what Sandberg refers to as ‘whole brain emulation,’ has become a distinct possibility arising from the feasibility of the functionalist paradigm and steady advances in computer science. Sandberg says we need a strategic plan to get going.
Levels of understanding
To start, Sandberg made two points about the kind of understanding that is required. First, we do not need to understand the function of a device to build it from parts, and second, we do not need to understand the function of the brain to emulate it. That said, Sandberg admitted that we still need to understand the brain’s lower level functions in order for us to be able to emulate them.
The known unknown
Sandberg also outlined the various levels of necessary detail; we can already start to parse through the “known unknown.” He asked, “what level of description is necessary to capture enough of a particular brain to mimic its function?”
He described several tiers that will require vastly more detail:

• Computational model
• Brain region connectivity
• Analog network population model
• Spiking neural network
• Electrophysiology
• Metabolome
• Proteome
• Etc. (and all the way down to the quantum level)

Requirements
Sandberg believes that the ability to scan an existing brain will be necessary. What will also be required is the proper scanning resolution. Once we can peer down to the sufficient detail, we should be able to construct a brain model; we will then be required to infer structure and low-level function.
Once this is done we can think about running a brain emulation. Requirements here will include a computational neuroscience model and the requisite computer hardware. Sandberg noted that body and environment simulations may be added to the emulation; the brain emulator, body simulator and environment simulator would be daisy-chained to each other to create the sufficient interactive link. The developers will also have to devise a way to validate their observations and results.
Neural simulations
Neural simulations are nothing new. Hodgkin and Huxley began working on these sorts of problems way back in 1952. The trick is to perfectly simulate neurons, neuron parts, synapses and chemical pathways. According to Sandberg, we are approaching 1-1 for certain systems, including the lamprey spinal cord and lobster ganglia.
Compartment models are also being developed with miniscule time and space resolutions. The current record is 22 million 6-compartment neurons, 11 billion synapses, and a simulation length of one second real-time. Sandberg cited advances made by the development of IBM’s Blue Gene.
Complications and Exotica
Sandberg also provided a laundry list of possible ‘complications and exotica’:

• dynamical state
• spinal cord
• volume transmission
• glial cells
• synaptic adaptation
• body chemical environment
• neurogensis
• ephaptic effects
• quantum computation
• analog computation
• randomness

Reverse engineering is all fine and well, suggested Sandberg, but how much function can be deduced from morphology (for example)?
Scanning
In regards to scanning, we’ll need to determine the kind of resolution and data needed. Sandberg argued that nondestructive scanning will be unlikely; MRIs have been the closest thus far but are limited to less than 7.7 micrometers resolution. More realistically, destructive scanning will likely be used; Sandberg noted such procedures as fixation and ‘slice and scan.’
Once scanning is complete the postprocessing can begin. Developers at this stage will be left wondering about the nature of the neurons and how they are all connected.
Given advances in computation, Sandberg predicted that whole brain emulation may arrive sometime between 2020 and 2060. As for environment and body simulation, we’ll have to wait until we have 100 terraflops at our disposal. We’ll also need a resolution of 5x5x50nm to do meaningful work.
Conclusions
Sandberg made mention of funding and the difficultly of finding scan targets. He named some subfields that lack drivers, namely basic neuroscience, electrophysiology, and large scale scanning (so far). He did see synergies arising from the ongoing development and industrialization of neuroscience, robotics and all the various –omics studies.
As for the order of development, Sandberg suggested 1) scanning and/or simulation, then 2) computer power, and then 3) the gradual emergence of emulation. Alternately, 1) first computer power, then 2) simulation and finally 3) scanning followed by 4) the rapid emergence of simulation.
Any volunteers for slice and scan?
George Dvorsky serves on the Board of Directors for the Institute for Ethics and Emerging Technologies. George is the Deputy-Editor of Betterhumans, co-founder and president of the Toronto Transhumanist Association, and the producer of Sentient Developments blog and podcast.

Gene for Left-Handed Trait Discovered




Gene for Left-Handed Trait Discovered
Kate Ravilious
for National Geographic News
August 1, 2007

The gene most closely linked to left-handedness has been found, experts announced this week.
The gene, called LRRTM1, is also associated with a slight increase in developing certain mental illnesses such as schizophrenia.
Clyde Francks is lead author of a new study on the gene and a visiting fellow at the Wellcome Trust Centre for Human Genetics at Oxford University.
For right-handed people, he said, the right side of the brain usually controls emotion, while the left side of the brain tends to control speech and language.
In left-handers—about 10 percent of the world's population—the pattern is usually reversed.
"We think that this gene affects the symmetry of the brain," Francks said. "LRRTM1 is not essential for left-handedness, but it can be a strong contributing factor."
Brain asymmetry is also a factor in schizophrenia, a mental disorder that affects about one in a hundred people worldwide and results in impaired perception and severe behavioral changes.
The researchers were not surprised when LRRTM1 also showed a possible impact on a person's chances of developing schizophrenia.
But Francks stressed that left-handers should not be unduly concerned about this link.
"There are many factors which make individuals more likely to develop schizophrenia," he said, "and the vast majority of left-handers will never develop a problem."
Finding Symmetry
Francks and his colleagues discovered the LRRTM1 gene during a study of a hundred families with dyslexic children.
The team was initially searching for a link between dyslexia—a neurological learning disability—and whether a person was left- or right-handed.
When the researchers took genetic samples from all the families involved, they noticed that a particular chromosome showed a correlation with handedness.
"We then started to study the chromosome in detail and found this gene," said Francks, whose work appears in the July 31 online advance issue of the journal Molecular Psychiatry.
People appear to inherit the gene from their fathers.
The team now intends to study the gene to try and tease out its full purpose and function.
"We need to find out what role it plays in brain development and at what point it is active, whether it is during fetal development, childhood, or adulthood," Francks said.
Paul Corry, director of public affairs at Rethink, a U.K.-based mental health charity, agrees that more work needs to be done to determine how the gene affects mental health.
LRRTM1 "may turn out to be part of a complex relationship between a range of genes and environmental factors that lead to people developing schizophrenia," Corry said.
The gene could also help scientists understand more about how humans evolved.
Most animals have brains that are more symmetric, experts note, including our closest genetic relatives, the apes.

Wednesday, August 01, 2007

The Whys of Mating: 237 Reasons and Counting

The Whys of Mating: 237 Reasons and Counting
By JOHN TIERNEY

Scholars in antiquity began counting the ways that humans have sex, but they weren’t so diligent in cataloging the reasons humans wanted to get into all those positions. Darwin and his successors offered a few explanations of mating strategies — to find better genes, to gain status and resources — but they neglected to produce a Kama Sutra of sexual motivations.
Perhaps you didn’t lament this omission. Perhaps you thought that the motivations for sex were pretty obvious. Or maybe you never really wanted to know what was going on inside other people’s minds, in which case you should stop reading immediately.
For now, thanks to psychologists at the University of Texas at Austin, we can at last count the whys. After asking nearly 2,000 people why they’d had sex, the researchers have assembled and categorized a total of 237 reasons — everything from “I wanted to feel closer to God” to “I was drunk.” They even found a few people who claimed to have been motivated by the desire to have a child.
The researchers, Cindy M. Meston and David M. Buss, believe their list, published in the August issue of Archives of Sexual Behavior, is the most thorough taxonomy of sexual motivation ever compiled. This seems entirely plausible.
Who knew, for instance, that a headache had any erotic significance except as an excuse for saying no? But some respondents of both sexes explained that they’d had sex “to get rid of a headache.” It’s No. 173 on the list.
Others said they did it to “help me fall asleep,” “make my partner feel powerful,” “burn calories,” “return a favor,” “keep warm,” “hurt an enemy” or “change the topic of conversation.” The lamest may have been, “It seemed like good exercise,” although there is also this: “Someone dared me.”
Dr. Buss has studied mating strategies around the world — he’s the oft-cited author of “The Evolution of Desire” and other books — but even he did not expect to find such varied and Machiavellian reasons for sex. “I was truly astonished,” he said, “by this richness of sexual psychology.”
The researchers collected the data by first asking more than 400 people to list their reasons for having sex, and then asking more than 1,500 others to rate how important each reason was to them. Although it was a fairly homogenous sample of students at the University of Texas, nearly every one of the 237 reasons was rated by at least some people as their most important motive for having sex.
The best news is that both men and women ranked the same reason most often: “I was attracted to the person.”
The rest of the top 10 for each gender were also almost all the same, including “I wanted to express my love for the person,” “I was sexually aroused and wanted the release” and “It’s fun.”
No matter what the reason, men were more likely to cite it than women, with a couple of notable exceptions. Women were more likely to say they had sex because, “I wanted to express my love for the person” and “I realized I was in love.” This jibes with conventional wisdom about women emphasizing the emotional aspects of sex, although it might also reflect the female respondents’ reluctance to admit to less lofty motives.
The results contradicted another stereotype about women: their supposed tendency to use sex to gain status or resources.
“Our findings suggest that men do these things more than women,” Dr. Buss said, alluding to the respondents who said they’d had sex to get things, like a promotion, a raise or a favor. Men were much more likely than women to say they’d had sex to “boost my social status” or because the partner was famous or “usually ‘out of my league.’ ”
Dr. Buss said, “Although I knew that having sex has consequences for reputation, it surprised me that people, notably men, would be motivated to have sex solely for social status and reputation enhancement.”
But then, men were also more likely than women to say they’d had sex because “I was slumming.” Or simply because “the opportunity presented itself,” or “the person demanded that I have sex.”
If nothing else, the results seem to be a robust confirmation of the hypothesis in the old joke: How can a woman get a man to take off his clothes? Ask him.
To make sense of the 237 reasons, Dr. Buss and Dr. Meston created a taxonomy with four general categories:

¶Physical: “The person had beautiful eyes” or “a desirable body,” or “was good kisser” or “too physically attractive to resist.” Or “I wanted to achieve an orgasm.”

¶Goal Attainment: “I wanted to even the score with a cheating partner” or “break up a rival’s relationship” or “make money” or “be popular.” Or “because of a bet.”

¶Emotional: “I wanted to communicate at a deeper level” or “lift my partner’s spirits” or “say ‘Thank you.’ ” Or just because “the person was intelligent.”

¶Insecurity: “I felt like it was my duty” or “I wanted to boost my self-esteem” or “It was the only way my partner would spend time with me.”

Having sex out of a sense of duty, Dr. Buss said, showed up in a separate study as being especially frequent among older women. But both sexes seem to practice a strategy that he calls mate-guarding, as illustrated in one of the reasons given by survey respondents: “I was afraid my partner would have an affair if I didn’t.”
That fear seems especially reasonable after you finish reading Dr. Buss’s paper and realize just how many reasons there are for infidelity. Some critics might complain that the list has some repetitions — it includes “I was curious about sex” as well as “I wanted to see what all the fuss was about” — but I’m more concerned about the reasons yet to be enumerated.
For instance, nowhere among the 237 reasons will you find the one attributed to the actress Joan Crawford: “I need sex for a clear complexion.” (The closest is “I thought it would make me feel healthy.”)Nor will you find anything about gathering rosebuds while ye may (the 17th-century exhortation to young virgins from Robert Herrick). Nor the similar hurry-before-we-die rationale (“The grave’s a fine and private place/ But none I think do there embrace”) from Andrew Marvell in “To His Coy Mistress.”
From even a cursory survey of literature or the modern mass market in sex fantasies, it seems clear that this new taxonomy may not be any more complete than the original periodic table of the elements.
When I mentioned Ms. Crawford’s complexion and the poets’ rationales to Dr. Buss, he promised to consider them and all other candidates for Reason 238.
You can nominate your own reasons at TierneyLab. You can also submit nominations for a brand new taxonomy: reasons for just saying “No way!” Somehow, though, I don’t think this list will be as long.


Copyright 2007 The New York Times Company


Further Reading

"Why Humans Have Sex." (PDF) Cindy M. Meston and David M. Buss. Archives of Sexual Behavior, August, 2007.

List of 237 Reasons for Having Sex (.doc). Cindy M. Meston and David M. Buss.

"The Evolution of Desire: Strategies of Human Mating." David Buss. Basic Books, 2003.

"To the Virgins, to Make Much of Time." Robert Herrick.

"To His Coy Mistress." Andrew Marvell.

"His Coy Mistress to Mr. Marvell." A. D. Hope, 2004.



Sunday, July 29, 2007

The Real Transformers


Stephen Lewis
Mertz Programmed for kindly conversation.


The Real Transformers
By ROBIN MARANTZ HENIG

I was introduced to my first sociable robot on a sunny afternoon in June. The robot, developed by graduate students at the Massachusetts Institute of Technology, was named Mertz. It had camera sensors behind its eyes, which were programmed to detect faces; when it found mine, the robot was supposed to gaze at me directly to initiate a kind of conversation. But Mertz was on the fritz that day, and one of its designers, a dark-haired young woman named Lijin Aryananda, was trying to figure out what was wrong with it. Mertz was getting fidgety, Aryananda was getting frustrated and I was starting to feel as if I were peeking behind the curtain of the Wizard of Oz.
Mertz consists of a metal head on a flexible neck. It has a childish computer-generated voice and expressive brows above its Ping-Pong-ball eyes — features designed to make a human feel kindly toward the robot and enjoy talking to it. But when something is off in the computer code, Mertz starts to babble like Chatty Cathy on speed, and it becomes clear that behind those big black eyes there’s truly nobody home.
In a video of Aryananda and Mertz in happier times, Aryananda can be seen leaning in, trying to get the robot’s attention by saying, “I’m your mother.” She didn’t seem particularly maternal on that June day, and Mertz didn’t seem too happy, either. It directed a stream of sentences at me in apparently random order: “You are too far away.” “Please teach me some colors.” “You are too far away.”
Maybe something was wrong with its camera sensor, Aryananda said. Maybe that was why it kept looking up at the ceiling and complaining. As she fiddled with the computer that runs the robot, I smiled politely — almost as much for the robot’s sake, I realized, as for the robot maker’s — and thought: Well, maybe it is the camera sensor, but if this thing wails “You are too far away” one more time, I’m going to throttle it.
At the Humanoid Robotics Group at M.I.T., a robot’s “humanoid” qualities can include fallibility and whininess as much as physical traits like head, arms and torso. This is where our cultural images of robots as superhumans run headlong into the reality of motors, actuators and cold computer code. Today’s humanoids are not the sophisticated machines we might have expected by now, which just shows how complicated a task it was that scientists embarked on 15 years ago when they began working on a robot that could think. They are not the docile companions of our collective dreams, robots designed to flawlessly serve our dinners, fold our clothes and do the dull or dangerous jobs that we don’t want to do. Nor are they the villains of our collective nightmares, poised for robotic rebellion against humans whose machine creations have become smarter than the humans themselves. They are, instead, hunks of metal tethered to computers, which need their human designers to get them going and to smooth the hiccups along the way.
But these early incarnations of sociable robots are also much more than meets the eye. Bill Gates has said that personal robotics today is at the stage that personal computers were in the mid-1970s. Thirty years ago, few people guessed that the bulky, slow computers being used by a handful of businesses would by 2007 insinuate themselves into our lives via applications like Google, e-mail, YouTube, Skype and MySpace. In much the same way, the robots being built today, still unwieldy and temperamental even in the most capable hands, probably offer only hints of the way we might be using robots in another 30 years.
Mertz and its brethren — at the Humanoid Robotics lab, at the Personal Robotics Lab across the street in another M.I.T. building and at similar laboratories in other parts of the United States, in Europe and in Japan — are still less like thinking, autonomous creatures than they are like fancy puppets that frequently break down. But what the M.I.T. robots may lack in looks or finesse, they make up for in originality: they are programmed to learn the way humans learn, through their bodies, their senses and the feedback generated by their own behavior. It is a more organic style of learning — though organic is, of course, a curious word to reach for to describe creatures that are so clearly manufactured.
Sociable robots come equipped with the very abilities that humans have evolved to ease our interactions with one another: eye contact, gaze direction, turn-taking, shared attention. They are programmed to learn the way humans learn, by starting with a core of basic drives and abilities and adding to them as their physical and social experiences accrue. People respond to the robots’ social cues almost without thinking, and as a result the robots give the impression of being somehow, improbably, alive.
At the moment, no single robot can do very much. The competencies have been cobbled together: one robot is able to grab a soup can when you tell it to put it on a shelf; another will look you in the eye and make babbling noises in keeping with the inflection of your voice. One robot might be able to learn some new words; another can take the perspective of a human collaborator; still another can recognize itself in a mirror. Taken together, each small accomplishment brings the field closer to a time when a robot with true intelligence — and with perhaps other human qualities, too, like emotions and autonomy — is at least a theoretical possibility. If that possibility comes to pass, what then? Will these new robots be capable of what we recognize as learning? Of what we recognize as consciousness? Will it know that it is a robot and that you are not?
The word “robot” was popularized in 1920, in the play “Rossum’s Universal Robots,” commonly called “R.U.R.,” by the Czech writer Karel Capek. The word comes from the Czech “robota,” meaning forced labor or drudgery. In the world of R.U.R., Robots (always with a capital R) are built to be factory workers, meaning they are designed as simply as possible, with no extraneous frills. “Robots are not people,” says the man who manufactures them. “They are mechanically more perfect than we are, they have an astounding intellectual capacity, but they have no soul.” Capek’s Robots are biological, not mechanical. The thing that separates them from humans is not the material they are made of — their skin is real skin; their blood, real blood — but the fact that they are built rather than born.
What separates the current crop of humanoid robots from humans is something harder to name. Because if roboticists succeed in programming their machines with a convincing version of social intelligence, with feelings that look like real feelings and thoughts that look like real thoughts, then all our fancy notions about our place in the universe start to get a little wobbly.
Eliminating the Cognition Box
We already live with many objects that are, in one sense, robots: the voice in a car’s Global Positioning System, for instance, which senses shifts in its own location and can change its behavior accordingly. But scientists working in the field mean something else when they talk about sociable robots. To qualify as that kind of robot, they say, a machine must have at least two characteristics. It must be situated, and it must be embodied. Being situated means being able to sense its environment and be responsive to it; being embodied means having a physical body through which to experience the world. A G.P.S. robot is situated but not embodied, while an assembly-line robot that repeats the same action over and over again is embodied but not situated. Sociable robots must be both, as well as exhibiting an understanding of social beings.
The push for sociable robots comes from two directions. One is pragmatic: if Bill Gates is right and the robots are coming, they should be designed in a way that makes them fit most naturally into the lives of ordinary people. The other is more theoretical: if a robot can be designed to learn the same way natural creatures do, this could be a significant boost for the field of artificial intelligence.
Both pragmatism and theory drive Rodney Brooks, author of “Flesh and Machines,” who until the end of last month was director of M.I.T.’s Computer Science and Artificial Intelligence Laboratory, home to the Humanoid Robotics lab that houses Mertz. Brooks is an electric, exaggerated personality, an Australian native with rubbery features and bulgy blue eyes. That mobile face and Aussie accent helped turn him into a cult figure after the 1997 theatrical release of “Fast, Cheap & Out of Control,” a documentary by Errol Morris that featured Brooks — along with a wild animal trainer, a topiary gardener and an expert in naked mole rats — as a man whose obsessions made him something of a misfit, a visionary with a restless, uncategorizable genius.
As Brooks sat with me in his office and reflected on his career from the vantage point of a 52-year-old about to return to full-time research — a man going through what he called “a scientific midlife crisis” — a theme emerged. Each time he faced a problem in artificial intelligence, he said, he looked for the implicit assumption that everyone else took for granted, and then he tried to negate it. In the 1980s, the implicit assumption was that abstract reasoning was the highest form of intelligence, the one that programmers should strive to imitate. This led to a focus on symbolic processing, on tough tasks like playing chess or solving problems in algebra or calculus. Tasks that, as Brooks slyly put it in “Flesh and Machines,” “highly educated male scientists found challenging.”
But Brooks wanted to build an artificial intelligence system that did the supposedly simple things, not mental acrobatics like chess but things that come naturally to any 4-year-old and that were eluding the symbolic processing capabilities of the computers. These cognitive tasks — visually distinguishing a cup from a chair, walking on two legs, making your way from bedroom to bathroom — were difficult to write into computer code because they did not require an explicit chain of reasoning; they just happened. And the way they happened was grounded in the fact that the 4-year-old had a body and that each action the child took provided more sensory information and, ultimately, more learning. This approach has come to be known as embodied intelligence.
That’s where the robots came in. Robots had bodies, and they could be programmed to use those bodies as part of their data gathering. Instead of starting out with everything they needed to know already programmed in, these robots would learn about the world the way babies do, starting with some simple competencies and adding to them through sensory input. For babies, that sensory input included seeing, touching and balancing. For robots, it would mean input from mechanical sensors like video cameras and gyroscopes.
In 1993, Brooks started to develop a new robot, a humanoid equipped with artificial intelligence, according to this new logic. His motivation was more theoretical than practical: to offer a new way of thinking about intelligence itself. Most artificial-intelligence programs at the time were designed from the top down, connecting all relevant processes of a robot — raw sensory input, perception, motor activity, behavior — in what was called a cognition box, a sort of centralized zone for all high-level computation. A walking robot, for instance, was programmed to go through an elaborate planning process before it took a step. It had to scan its location, obtain a three-dimensional model of the terrain, plan a path between any obstacles it had detected, plan where to put its right foot along that path, plan the pressures on each joint to get its foot to that spot, plan how to twist the rest of its body to make its right foot move and plan the same set of behaviors for placing its left foot at the next spot along the path, and then finally it would move its feet.
Brooks turned the top-down approach on its head; he did away with the cognition box altogether. “No cognition,” he wrote in “Flesh and Machines.” “Just sensing and action.” In effect, he wrote, he was leaving out what was thought to be the “intelligence” part of “artificial intelligence.” The way Brooks’s robot was designed to start walking, he wrote, was “by moving its feet.”
This was the approach that Brooks and his team used to design their humanoid robot. This one couldn’t walk. The robot, named Cog, was stationary, a big man-size metal torso with big man-size arms that spanned six and a half feet when extended. But it was designed to think. Perched on a pedestal almost three feet high, it seemed to hulk over its human creators, dominating the Humanoid Robotics lab from 1993 until it was retired 11 years later and put on permanent display at the M.I.T. Museum. (It has been lent out as part of a traveling exhibit, “Robots + Us,” currently at the Notebaert Nature Museum in Chicago.) Its presence was disarming, mostly because it was programmed to look at anything that moved. As one visitor to the lab put it: “Cog ‘noticed’ me soon after I entered its room. Its head turned to follow me, and I was embarrassed to note that this made me happy.”
Cog was designed to learn like a child, and that’s how people tended to treat it, like a child. Videos of graduate students show them presenting Cog with a red ball to track, a waggling hand to look at, a bright pink Slinky to manipulate — the toys children are given to explore the world, to learn some basic truths about anatomy and physics and social interactions. As the robot moved in response to the students’ instructions, it exhibited qualities that signaled “creature.” The human brain has evolved to interpret certain traits as indicators of autonomous life: when something moves on its own and with apparent purpose, directs its gaze toward the person with whom it interacts, follows people with its eyes and backs away if someone gets too close. Cog did all these things, which made people who came in contact with it think of it as something alive. Even without a face, even without skin, even without arms that looked like arms or any legs at all, there was something creaturelike about Cog. It took very little, just the barest suggestion of a human form and a pair of eyes, for people to react to the robot as a social being.
In addition, Cog was programmed to learn new things based on its sensory and motor inputs, much as babies learn new things by seeing how their bodies react to and affect their surroundings. Cog’s arm motors, for instance, were calibrated to respond to the weight of a held object. When a student handed a Slinky to Cog, the oscillators in its elbowlike joints gave feedback about the toy’s weight and position. After a few hours of practice, the robot could make the Slinky slither by raising and lowering its arms. If it was given a heavier Slinky or a drumstick, it would be able to adjust its motions accordingly. The learning was minimal, but it was a start — and it was, significantly, learning derived from the input of motors, gears and oscillators, the robot equivalent of muscles.
Cog was able to learn other things too, including finding and naming objects it had never seen before. (The robot had microphones for ears and was equipped with some basic speech recognition software and an artificial voice.) But while Brooks showed a kind of paternal delight in what the robot could do, he was hesitant to give it the label of “learning” per se. “I am so careful about saying that any of our robots ‘can learn,’ ” he wrote in an e-mail message. “They can only learn certain things, just like a rat can learn only certain things and a chimpanzee can only learn certain things and even [you] can only learn certain things.” Even now, 14 years after the Cog project began, each of today’s humanoid robots can still only learn a very small number of things.
Cynthia Breazeal came to Brooks’s lab as a graduate student in 1990 and did much of the basic computational work on Cog. In 1996, when it was time for Breazeal to choose a doctoral project, she decided to develop a sociable robot of her own. Her goals were as much pragmatic as theoretical; she said she hoped her robot would be a model for how to design the domestic robots of the future. The one she built had an animated head with big blue eyes, flirty lashes, red lips that curved upward or downward depending on its mood and pink ears that did the same. She called the robot Kismet, after the Turkish word for fate.
How Smart Can a Robot Be?
Kismet was the most expressive sociable robot built to that point, even though it consisted of only a hinged metal head on a heavy base, with wires and motors visible and eyes and lips stuck on almost like an afterthought. Breazeal is now 39 years old, an associate professor at M.I.T. and director of the Personal Robotics Group. She retains a polished, youthful prettiness, amplified these days by a late pregnancy with her third child. When she talks about Kismet, she is careful to call it “it” instead of a more animate pronoun like “he” or “she.” But her voice softens, her rapid-fire speech slows a little and it can be difficult to tell from her tone of voice whether she’s describing her robot or one of her two preschool-age sons.

The robot expressed a few basic emotions through changes in its facial expression — that is, through the positioning of its eyes, lips, eyebrows and pink paper ears. The emotions were easy for an observer to recognize: anger, fear, disgust, joy, surprise, sorrow. According to psychologists, these expressions are automatic, unconscious and universally understood. So when the drivers on Kismet’s motors were set to make surprise look like raised eyebrows, wide-open eyes and a rounded mouth, the human observer knew exactly what was going on.
Kismet’s responses to stimulation were so socially appropriate that some people found themselves thinking that the robot was actually feeling the emotions it was displaying. Breazeal realized how complicated it was to try to figure out what, or even whether, Kismet was feeling. “Robots are not human, but humans aren’t the only things that have emotions,” she said. “The question for robots is not, Will they ever have human emotions? Dogs don’t have human emotions, either, but we all agree they have genuine emotions. The question is, What are the emotions that are genuine for the robot?”
Unlike Cog’s, Kismet’s learning was more social than cognitive. What made the robot so lifelike was its ability to have what Breazeal called “proto-conversations” with a variety of human interlocutors. Run by 15 parallel computers operating simultaneously, Kismet was programmed to have the same basic motivations as a 6-month-old child: the drive for novelty, the drive for social interaction and the drive for periodic rest. The behaviors to achieve these goals, like the ability to look for brightly colored objects or to recognize the human face, were also part of Kismet’s innate program. So were the facial behaviors that reflected Kismet’s mood states — aroused, bored or neutral — which changed according to whether the robot’s basic drives were being satisfied.
The robot was a model for how these desires and emotions are reflected in facial expression and how those expressions in turn affect social interaction. Take the drive for novelty. With no stimulus nearby, Kismet’s eyes would droop in apparent boredom. Then a lovely thing happened. If there was a person nearby, she would see Kismet’s boredom and wave a toy in front of the robot’s eyes. This activated Kismet’s program to look for brightly colored objects, which in turn moved the robot into its “aroused” affective state, with a facial expression with the hallmarks of happiness. The happy face, in turn, led the human to feel good about the interaction and to wave the toy some more — a socially gratifying feedback loop akin to playing with a baby.
Kismet is now retired and on permanent display, inert as a bronze statue, at the M.I.T. Museum. The most famous robot now in Breazeal’s lab, the one that the graduate students compete for time with, looks nothing like Kismet. It is a three-foot-tall, head-to-toe creature, sort of a badger, sort of a Yoda, with big eyes, enormous pointy ears, a mouth with soft lips and tiny teeth, a furry belly, furry legs and pliable hands with real-looking fingernails. The reason the robot, called Leonardo (Leo for short), is so lifelike is that it was made by Hollywood animatronics experts at the Stan Winston Studio. (Breazeal consulted with the studio on the construction of the robotic teddy bear in the 2001 Steven Spielberg film “A.I.”) As soon as Leo arrived in the lab, Breazeal said, her students started dismantling it, stripping out all the remote-control wiring and configuring it instead with a brain and body that operated not by remote control but by computer-based artificial intelligence.
I had studied the videos posted on the M.I.T. Media Lab Web site, and I was fond of Leo even before I got to Cambridge. I couldn’t wait to see it close up. I loved the steadiness of its gaze, the slow way it nodded its head and blinked when it understood something, the little Jack Benny shrug it gave when it didn’t. I loved how smart it seemed. In one video, two graduate students, Jesse Gray and Matt Berlin, engaged it in an exercise known in psychology as the false-belief test. Leo performed remarkably. Some psychologists contend that very young children think all minds are permeable and that everyone knows exactly what they themselves know. Older children, after the age of about 4 or 5, have learned that different people have different minds and that it is possible for someone else to hold beliefs that the children themselves know to be false. Leo performed in the video like a sophisticated 5-year-old, one who had developed what psychologists call a theory of mind.
In the video, Leo watches Jesse Gray, who is wearing a red T-shirt, put a bag of chips into Box 1 and a bag of cookies into Box 2, while Matt Berlin, in a brown T-shirt, also watches. After Berlin leaves the room, Gray switches the items, so that now the cookies are in Box 1 and the chips are in Box 2. Gray locks the two boxes and leaves the room, and Leo now knows what Gray knows: the new location for the chips and cookies. But it also knows that Berlin doesn’t know about the switch. Berlin still thinks there are chips in Box 1.
The amazing part comes next. Berlin, in the brown T-shirt, comes back into the room and tries to open the lock on the first box. Leo sees Berlin struggling, and it decides to help by pressing a lever that will deliver to Berlin the item he’s looking for. Leo presses the lever for the chips. It knows that there are cookies in the box that Berlin is trying to open, but it also knows — and this is the part that struck me as so amazing — that Berlin is trying to open the box because he wants chips. It knows that Berlin has a false belief about what is in the first box, and it also knows what Berlin wants. If Leo had indeed passed this important developmental milestone, I wondered, could it also be capable of all sorts of other emotional tasks: empathy, collaboration, social bonding, deception?
Unfortunately, Leo was turned off the day I arrived, inertly presiding over one corner of the lab like a fuzzy Buddha. Berlin and Gray and their colleague, Andrea Thomaz, a postdoctoral researcher, said that they would be happy to turn on the robot for me but that the process would take time and that I would have to come back the next morning. They also wanted to know what it was in particular that I wanted to see Leo do because, it turned out, the robot could go through its paces only when the right computer program was geared up. This was my first clue that Leo maybe wasn’t going to turn out to be quite as clever as I had thought.
When I came back the next day, Berlin and Gray were ready to go through the false-belief routine with Leo. But it wasn’t what I expected. I could now see what I had seen on the video. But in person, I could also peek behind the metaphoric curtain and see something that the video camera hadn’t revealed: the computer monitor that showed what Leo’s cameras were actually seeing and another monitor that showed the architecture of Leo’s brain. I could see that this wasn’t a literal demonstration of a human “theory of mind” at all. Yes, there was some robotic learning going on, but it was mostly a feat of brilliant computer programming, combined with some dazzling Hollywood special effects.
It turned out Leo wasn’t seeing the young men’s faces or bodies; it was seeing something else. Gray and Berlin were each wearing a headband and a glove, which I hadn’t noticed in the video, and the robot’s optical motion tracking system could see nothing but the unique arrangements of reflective tape on their accessories. What the robot saw were bunches of dots. Dots in one geometric arrangement meant Person A; in a different arrangement, they meant Person B. There was a different arrangement of tape on the two different snacks, too, and also on the two different locks for the boxes. On a big monitor alongside Leo was an image of what was going on inside its “brain”: one set of dots represented Leo’s brain; another set of dots represented Berlin’s brain; a third set of dots represented Gray’s. The robot brain was programmed to keep track of it all.
Leo did not learn about false beliefs in the same way a child did. Robot learning, I realized, can be defined as making new versions of a robot’s original instructions, collecting and sorting data in a creative way. So the learning taking place here was not Leo’s ability to keep track of which student believed what, since that skill had been programmed into the robot. The learning taking place was Leo’s ability to make inferences about Gray’s and Berlin’s actions and intentions. Seeing that Berlin’s hand was near the lock on Box 1, Leo had to search through its internal set of task models, which had been written into its computer program, and figure out what it meant for a hand to be moving near a lock and not near, say, a glass of water. Then it had to go back to that set of task models to decide why Berlin might have been trying to open the box — that is, what his ultimate goal was. Finally, it had to convert its drive to be helpful, another bit of information written into its computer program, into behavior. Leo had to learn that by pressing a particular lever, it could give Berlin the chips he was looking for. Leo’s robot learning consisted of integrating the group of simultaneous computer programs with which it had begun.
Leo’s behavior might not have been an act of real curiosity or empathy, but it was an impressive feat nonetheless. Still, I felt a little twinge of disappointment, and for that I blame Hollywood. I’ve been exposed to robot hype for years, from the TV of my childhood — Rosie the robot maid on “The Jetsons,” that weird talking garbage-can robot on “Lost in Space” — to the more contemporary robots-gone-wild of films like “Blade Runner” and “I, Robot.” Despite my basic cold, hard rationalism, I was prepared to be bowled over by a robot that was adorable, autonomous and smart. What I saw in Leo was no small accomplishment in terms of artificial intelligence and the modeling of human cognition, but it was just not quite the accomplishment I had been expecting. I had been expecting something closer to “real.”
Why We Might Want to Hug a Desk Lamp
I had been seduced by Leo’s big brown eyes, just like almost everyone else who encounters the robot, right down to the students who work on its innards. “There we all are, soldering Leonardo’s motors, aware of how it looks from behind, aware that its brain is just a bunch of wires,” Guy Hoffman, a graduate student, told me. Yet as soon as they get in front of it, he said, the students see its eyes move, see its head turn, see the programmed chest motion that looks so much like breathing, and they start talking about Leo as a living thing.
People do the same thing with a robotic desk lamp that Hoffman has designed to move in relation to a user’s motions, casting light wherever it senses the user might need it. It’s just a lamp with a bulky motor-driven neck; it looks nothing like a living creature. But, he said, “as soon as it moves on its own and faces you, you say: ‘Look, it’s trying to help me.’ ‘Why is it doing that?’ ‘What does it want from me?’ ”
When something is self-propelled and seems to engage in goal-directed behavior, we are compelled to interpret those actions in social terms, according to Breazeal. That social tendency won’t turn off when we interact with robots. But instead of fighting it, she said, “we should embrace it so we can design robots in a way that makes sense, so we can integrate robots into our lives.”
The brain activity of people who interacted with Cog and Kismet, and with their successors like Mertz, is probably much the same as the brain activity of someone interacting with a real person. Neuroscientists recently found a collection of brain cells called mirror neurons, which become activated in two different contexts: when someone performs an activity and when someone watches another person perform the same activity. Mirror-neuron activation is thought to be the root of such basic human drives as imitation, learning and empathy. Now it seems that mirror neurons fire not only when watching a person but also when watching a humanoid robot. Scientists at the University of California, San Diego, reported last year that brain scans of people looking at videos of a robotic hand grasping things showed activity in the mirror neurons. The work is preliminary, but it suggests something that people in the M.I.T. robotics labs have already seen: when these machines move, when they direct their gaze at you or lean in your direction, they feel like real creatures.
Would a Robot Make a Better Boyfriend?
Cog, Kismet and Mertz might feel real, but they look specifically and emphatically robotic. Their gears and motors show; they have an appealing retro-techno look, evoking old-fashioned images of the future, not too far from the Elektro robot of the 1939 World’s Fair, which looked a little like the Tin Man of “The Wizard of Oz.” This design was in part a reflection of a certain kind of aesthetic sensibility and in part a deliberate decision to avoid making robots that look too much like us.
Another robot-looking robot is Domo, whose stylized shape somehow evokes the Chrysler Building almost as much as it does a human. It can respond to some verbal commands, like “Here, Domo,” and can close its hand around whatever is placed in its palm, the way a baby does. Shaking hands with Domo feels almost like shaking hands with something alive. The robot’s designer, Aaron Edsinger, has programmed it to do some domestic tricks. It can grab a box of crackers placed in its hand and put it on a shelf and then grab a bag of coffee beans — with a different grip, based on sensors in its mechanical hand — and put it, too, on a shelf. Edsinger calls this “helping with chores.” Domo tracks objects with its big blue eyes and responds to verbal instructions in a high-pitched artificial voice, repeating the words it hears and occasionally adding an obliging “O.K.”
Domo’s looks are just barely humanoid, but that probably works to its advantage. Scientists believe that the more a robot looks like a person, the more favorably we tend to view it, but only up to a point. After that, our response slips into what the Japanese roboticist Masahiro Mori has called the “uncanny valley.” We start expecting too much of the robots because they so closely resemble real people, and when they fail to deliver, we recoil in something like disgust.
If a robot had features that made it seem, say, 50 percent human, 50 percent machine, according to this view, we would be willing to fill in the blanks and presume a certain kind of nearly human status. That is why robots like Domo and Mertz are interpreted by our brains as creaturelike. But if a robot has features that make it appear 99 percent human, the uncanny-valley theory holds that our brains get stuck on that missing 1 percent: the eyes that gaze but have no spark, the arms that move with just a little too much stiffness. This response might be akin to an adaptive revulsion at the sight of corpses. A too-human robot looks distressingly like a corpse that moves.
This zombie effect is one aspect of a new discipline that Breazeal is trying to create called human-robot interaction. Last March, Breazeal and Alan Schultz of the Naval Research Laboratory convened the field’s second annual conference in Arlington, Va., with presentations as diverse as describing how people react to instructions to “kill” a humanoid robot and a film festival featuring videos of human-robot interaction bloopers.
To some observers, the real challenge is not how to make human-robot interaction smoother and more natural but how to keep it from overshadowing, and eventually seeming superior to, a different, messier, more complicated, more flawed kind of interaction — the one between one human and another. Sherry Turkle, a professor in the Program in Science, Technology and Society at M.I.T., worries that sociable robots might be easier to deal with than people are and that one day we might actually prefer our relationships with our machines. A female graduate student once approached her after a lecture, Turkle said, and announced that she would gladly trade in her boyfriend for a sophisticated humanoid robot as long as the robot could produce what the student called “caring behavior.” “I need the feeling of civility in the house,” she told Turkle. “If the robot could provide a civil environment, I would be happy to help produce the illusion that there is somebody really with me.” What she was looking for, the student said, was a “no-risk relationship” that would stave off loneliness; a responsive robot, even if it was just exhibiting scripted behavior, seemed better to her than an unresponsive boyfriend.
The encounter horrified Turkle, who thought it revealed how dangerous, and how seductive, sociable robots could be. “They push our Darwinian buttons,” she told me. Sociable robots are programmed to exhibit the kind of behavior we have come to associate with sentience and empathy, she said, which leads us to think of them as creatures with intentions, emotions and autonomy: “You see a robot like that as a creature; you feel a desire to nurture it. And with this desire comes the fantasy of reciprocation. You begin to care for these creatures and to want the creatures to care about you.”
If Lijin Aryananda, Brooks’s former student, had ever wanted Mertz to “care” about her, she certainly doesn’t anymore. On the day she introduced me to Mertz, Aryananda was heading back to a postdoctoral research position at the University of Zurich. Her new job is in the Artificial Intelligence Lab, and she will still be working with robots, but Aryananda said she wants to get as far away as possible from humanoids and from the study of how humans and robots interact.
“Anyone who tells you that in human-robot interactions the robot is doing anything — well, he is just kidding himself,” she told me, grumpy because Mertz was misbehaving. “Whatever there is in human-robot interaction is there because the human puts it there.”
Nagging, a Killer App
The building and testing of sociable robots remains a research-based enterprise, and when the robots do make their way out of the laboratory, it is usually as part of somebody’s experiment. Breazeal is now overseeing two such projects. One is the work of Cory Kidd, a graduate student who designed and built 17 humanoid robots to serve as weight-loss coaches. The robot coach, a child-size head and torso holding a small touch screen, is called Autom. It is able, using basic artificial-voice software, to speak approximately 1,000 phrases, things like “It’s great that you’re doing well with your exercise” or “You should congratulate yourself on meeting your calorie goals today.” It is programmed to get a little more informal as time goes on: “Hello, I hope that we can work together” will eventually shift to “Hi, it’s good to see you again.” It is also programmed to refer to things that happened on other days, with statements like “It looks like you’ve had a little more to eat than usual recently.”
Kidd is recruiting 15 volunteers from around Boston to take Autom into their homes for six weeks. They will be told to interact with the robot at least once a day, recording food intake and exercise on its touch screen. The plan is to compare their experiences with those of two other groups of 15 dieters each. One group will interact with the same weight-loss coaching software through a touch screen only; the other will record daily food intake and exercise the old-fashioned way, with paper and pen. Kidd said that the study is too short-term to use weight loss as a measure of whether the robot is a useful dieting aid. But at this point, his research questions are more subjective anyway: Do participants feel more connected to the robot than they do to the touch screen? And do they think of that robot on the kitchen counter as an ally or a pest?
Breazeal’s second project is more ambitious. In collaboration with Rod Grupen, a roboticist at the University of Massachusetts in Amherst, she is designing and building four toddler-size robots. Then she will put them into action at the Boston Science Museum for two weeks in June 2009. The robots, which will cost several hundred thousand dollars each, will roll around in what she calls “a kind of robot Romper Room” and interact with a stream of museum visitors. The goal is to see whether the social competencies programmed into these robots are enough to make humans comfortable interacting with them and whether people will be able to help the robots learn to do simple tasks like stacking blocks.
The bare bones of the toddler robots already exist, in the form of a robot designed in Grupen’s lab called uBot-5. A few of these uBots are now being developed for use in assisted-living centers in research designed to see how the robots interact with the frail elderly. Each uBot-5 is about three feet tall, with a big head, very long arms (long enough to touch the ground, should the arms be needed for balance) and two oversize wheels. It has big eyes, rubber balls at the ends of its arms and a video screen for a face. (Breazeal’s version will have sleek torsos, expressive faces and realistic hands.) In one slide that Grupen uses in his PowerPoint presentations, the uBot-5 robot is holding a stethoscope to the chest of a woman lying on the ground after a simulated fall. The uBot is designed to connect by video hookup to a health care practitioner, but still, the image of a robot providing even this level of emergency medical care is, to say the least, disconcerting.
Does It Know It’s a Robot?
More disconcerting still is the image of a robot looking at itself in the mirror and waving hello — a robot with a primitive version of self-awareness. A first step in this direction occurred in September 2004 with reports from Yale about Nico, a humanoid robot. Nico, its designers announced, was able to recognize itself in a mirror. One of its creators, Brian Scassellati, earned his doctorate in 2001 at M.I.T., where he worked on Cog and Kismet — to which Nico bears a family resemblance. Nico has visible workings, a head, arms and torso made of steel and a graceful tilt to its shoulders and neck. Like the M.I.T. robots, Nico has no legs, because Scassellati, now an associate professor of computer science at Yale, wanted to concentrate on what it could do with its upper body and, in particular, the cameras in its eyes.
Here is how Nico learned to recognize itself. The robot had a camera behind its eye, which was pointed toward a mirror. When a reflection came back, Nico was programmed to assign the image a score based on whether it was most likely to be “self,” “another” or “neither.” Nico was also programmed to move its arm, which sent back information to the computer about whether the arm was moving. If the arm was moving and the reflection in the mirror was also moving, the program assigned the image a high probability of being “self.” If the reflection moved but Nico’s arm was not moving, the image was assigned a high probability of being “another.” If the image did not move at all, it was given a high probability of being “neither.”
Nico spent some time moving its arm in front of the mirror, so it could learn when its motor sensors were detecting arm movement and what that looked like through its camera. It learned to give that combination a high score for “self.” Then Nico and Kevin Gold, a graduate student, stood near each other, looking into the mirror, as the robot and the human took turns moving their arms. In 20 runs of the experiment, Nico correctly identified its own moving arm as “self” and Gold’s purposeful flailing as “another.”
One way to interpret this might be to conclude that Nico has a kind of self-awareness, at least when in motion. But that would be quite a leap. Robot consciousness is a tricky thing, according to Daniel Dennett, a Tufts philosopher and author of “Consciousness Explained,” who was part of a team of experts that Rodney Brooks assembled in the early 1990s to consult on the Cog project. In a 1994 article in The Philosophical Transactions of the Royal Society of London, Dennett posed questions about whether it would ever be possible to build a conscious robot. His conclusion: “Unlikely,” at least as long as we are talking about a robot that is “conscious in just the way we human beings are.” But Dennett was willing to credit Cog with one piece of consciousness: the ability to be aware of its own internal states. Indeed, Dennett believed that it was theoretically possible for Cog, or some other intelligent humanoid robot in the future, to be a better judge of its own internal states than the humans who built it. The robot, not the designer, might some day be “a source of knowledge about what it is doing and feeling and why.”
But maybe higher-order consciousness is not even the point for a robot, according to Sidney Perkowitz, a physicist at Emory. “For many applications,” he wrote in his 2004 book, “Digital People: From Bionic Humans to Androids,” “it is enough that the being seems alive or seems human, and irrelevant whether it feels so.”
In humans, Perkowitz wrote, an emotional event triggers the autonomic nervous system, which sparks involuntary physiological reactions like faster heartbeat, increased blood flow to the brain and the release of certain hormones. “Kismet’s complex programming includes something roughly equivalent,” he wrote, “a quantity that specifies its level of arousal, depending on the stimulus it has been receiving. If Kismet itself reads this arousal tag, the robot not only is aroused, it knows it is aroused, and it can use this information to plan its future behavior.” In this way, according to Perkowitz, a robot might exhibit the first glimmers of consciousness, “namely, the reflexive ability of a mind to examine itself over its own shoulder.”
Robot consciousness, it would seem, is related to two areas: robot learning (the ability to think, to reason, to create, to generalize, to improvise) and robot emotion (the ability to feel). Robot learning has already occurred, with baby steps, in robots like Cog and Leonardo, able to learn new skills that go beyond their initial capabilities. But what of emotion? Emotion is something we are inclined to think of as quintessentially human, something we only grudgingly admit might be taking place in nonhuman animals like dogs and dolphins. Some believe that emotion is at least theoretically possible for robots too. Rodney Brooks goes so far as to say that robot emotions may already have occurred — that Cog and Kismet not only displayed emotions but, in one way of looking at it, actually experienced them.
“We’re all machines,” he told me when we talked in his office at M.I.T. “Robots are made of different sorts of components than we are — we are made of biomaterials; they are silicon and steel — but in principle, even human emotions are mechanistic.” A robot’s level of a feeling like sadness could be set as a number in computer code, he said. But isn’t a human’s level of sadness basically a number, too, just a number of the amounts of various neurochemicals circulating in the brain? Why should a robot’s numbers be any less authentic than a human’s?
“If the mechanistic explanation is right, then one can in principle make a machine which is living,” he said with a grin. That explains one of his longtime ultimate goals: to create a robot that you feel bad about switching off.
The permeable boundary between humanoid robots and humans has especially captivated Kathleen Richardson, a graduate student in anthropology at Cambridge University in England. “I wanted to study what it means to be human, and robots are a great way to do that,” she said, explaining the 18 months she spent in Brooks’s Humanoid Robotics lab in 2003 and 2004, doing fieldwork for her doctorate. “Robots are kind of ambiguous, aren’t they? They’re kind of like us but not like us, and we’re always a bit uncertain about why.”
To her surprise, Richardson found herself just as fascinated by the roboticists at M.I.T. as she was by the robots. She observed a kinship between human and humanoid, an odd synchronization of abilities and disabilities. She tried not to make too much of it. “I kept thinking it was merely anecdotal,” she said, but the connection kept recurring. Just as a portrait might inadvertently give away the painter’s own weaknesses or preoccupations, humanoid robots seemed to reflect something unintended about their designers. A shy designer might make a robot that’s particularly bashful; a designer with physical ailments might focus on the function — touch, vision, speech, ambulation — that gives the robot builder the greatest trouble.
“A lot of the inspiration for the robots seems to come from some kind of deficiency in being human,” Richardson, back in England and finishing her dissertation, told me by telephone. “If we just looked at a machine and said we want the machine to help us understand about being human, I think this shows that the model of being human we carry with us is embedded in aspects of our own deficiencies and limitations.” It’s almost as if the scientists are building their robots as a way of completing themselves.
“I want to understand what it is that makes living things living,” Rodney Brooks told me. At their core, robots are not so very different from living things. “It’s all mechanistic,” Brooks said. “Humans are made up of biomolecules that interact according to the laws of physics and chemistry. We like to think we’re in control, but we’re not.” We are all, human and humanoid alike, whether made of flesh or of metal, basically just sociable machines.

Robin Marantz Henig is a contributing writer. Her last article for the magazine was about evolutionary theories of religion.


Copyright 2007 The New York Times Company