Friday, July 20, 2007

Viagra may lessen effects of jet lag




Circadian fix: Viagra may lessen effects of jet lag
N. Seppa

The leading drug prescribed for male impotence can counteract the lethargy caused by a disruption in the sleep cycle, a study in rodents suggests. Sildenafil, commonly known as Viagra, helps hamsters rebound from a 6-hour clock change such as a long eastbound plane flight produces.
To mimic conditions that can lead to jet lag, scientists habituated hamsters to a daily routine of 14 hours of light and 10 hours of darkness. The researchers then abruptly switched on the lights 6 hours early and continued the same light-to-dark routine from that point onward, simulating the effects of a flight from Chicago to London.
Just before changing the hamsters' routine, the researchers injected each animal with either sildenafil or saline solution. Then, they observed how long it took the hamsters to restart their daily habit of running on a wheel.
Hamsters receiving a large single dose of sildenafil resynchronized their body clocks and resumed their usual wheel routines within 6 days. Hamsters getting a lower dose took 8 days, whereas those receiving the inert injection took 12 days, the scientists report in an upcoming issue of the Proceedings of the National Academy of Sciences.
Circadian rhythm in mammals is controlled mainly by neurons in the hypothalamus, says study coauthor Patricia V. Agostino, a neuroscientist at the National University of Quilmes in Bernal, Argentina. When the vision system detects light, it sends stimuli to the hypothalamus and sets off a series of events that generate wakefulness. "Light is the main synchronizer of the circadian clock," Agostino says.
A compound called cyclic guanine monophosphate (cyclic GMP) plays a role in regulating circadian rhythm. In the hamster study, scientists measured the animals' blood concentrations of cyclic GMP 45 minutes before changing the light-dark schedule. Compared with hamsters receiving saline shots, the animals injected with sildenafil had double the amount of cyclic GMP. Sildenafil shuts down enzymes that would limit cyclic GMP production, but Agostino's team isn't certain that this is how the drug restores circadian rhythm.
"This resetting of the clock seems to be novel," says pharmacologist Joseph A. Beavo of the University of Washington School of Medicine in Seattle. He cautions that the new research is only on rodents, but since sildenafil is a widely used drug, a sampling of men who travel frequently and take it might turn up any stabilizing effect on circadian rhythm, he says.
Most travelers who experience jet lag find that the effects are strongest after an eastbound flight, which shortens the day and pushes the circadian clock forward. Interestingly, sildenafil's circadian re-adjustment worked only in animals whose circadian rhythms had been advanced, Agostino says. That suggests that the drug would work for eastbound travelers and airline personnel, as well as some shift workers, she says.

COPYRIGHT 2007 Science Service, Inc.
COPYRIGHT 2007 Gale Group

44 comments:

female viagra said...

Wow, nice post,there are many person searching about that now they will find enough resources by your post.Thank you for sharing to us.Please one more post about that..

Anonymous said...

viagra erektionsdauer viagra bluthochdruck reimport viagra rezept viagra viagra ungarn viagra für die frau kaufen viagra kostüm viagra kaufen rezeptfrei viagra selbst machen viagra mit 20 jahren

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

wirkungszeit viagra viagra benutzung viagra auch ohne rezept viagra in hamburg viagra rezeptfrei in der apotheke alternativen für viagra woher kriege ich viagra alkohol mit viagra rezeptfrei viagra bestellen was ist viagra

Anonymous said...

viagra auswirkung viagra in österreich kaufen kamagra pille 100mg viagra generika viagra kaufen in deutschland viagra im internet bestellen viagra maus cumpara viagra viagra und hoher blutdruck das erste mal viagra viagra und betablocker

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra schwarzmarkt viagra funktioniert nicht arginin und viagra gel viagra pfizers viagra levitra viagra cialis vergleich viagra wirkt nach viagra und nitro diovan viagra viagra und betablocker

Anonymous said...

viagra selbst gemacht viagra dealer beste viagra gelbe viagra viagra über internet viagra forum bestellen viagra langzeitwirkung gruppa viagra viagra spinne viagra preise deutschland

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

herzinfarkt und viagra köpa viagra türkisch viagra aspirin viagra synonym viagra viagra russland kamagra pille 100mg viagra generika viagra kosten apotheke niederlande viagra ist viagra verschreibungspflichtig

Anonymous said...

viagra therapie viagra langzeitwirkung viagra verwendung arzneimittel viagra viagra testen viagra ohne verschreibung king viagra viagra versand viagra filmtabletten apotheke online viagra

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra oder ähnliches ohne rezept viagra nürnberg viagra kaufen in österreich viagra anleitung viagra privat kaufen viagra nitro viagra für diabetiker viagra ähnlich viagra dauerständer viagra spam mails

Anonymous said...

ibro berilo viagra türkisches viagra viagra gedicht verschreibung viagra pfizer viagra 50mg viagra 1 tablette viagra kopfschmerzen hgl viagra viagra 100 mg 12 st viagra vorzeitiger samenerguss

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra selbst machen viagra einnahme viagra gedicht thai viagra viagra in den niederlanden viagra sicher online kaufen viagra und nebenwirkungen viagra in indien do czego jest viagra vergleich viagra

Anonymous said...

viagra rezeptfrei holland günstiger viagra viagra suche viagra linz viagra aus der apotheke apotheken online viagra viagra preisvergleich viagra legal erwerben viagra in belgien kaufen viagra pfitzner

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra und mehr viagra pfizer preise apotheke holland viagra cgmp viagra viagra einkaufen viagra online apotheke viagra legal kaufen viagra bei gesunden männern koks und viagra viagra lieferung

Anonymous said...

viagra in brasilien amlodipin viagra cialis contra viagra antibiotika viagra lungenhochdruck viagra viagra schäden unterschied viagra levitra viagra nachbau viagra woher macht viagra impotent

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

luxemburg viagra viagra und poppers herzinfarkt viagra viagra ähnliches viagra online rezept wirkt wie viagra viagra selbst herstellen viagra für den mann gegenteil viagra viagra packstation

Anonymous said...

ephedrin viagra schlange viagra viagra preis apotheke viagra urologe arzneimittel viagra viagra sport viagra samenerguss viagra heilung viagra einkaufen viagra bestellen online

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra positive nebenwirkungen viagra wirkmechanismus viagra wirkmechanismus verfallsdatum viagra viagra bericht ibro berilo viagra peter lenz viagra preise von viagra viagra zu verkaufen viagra bestellung

Anonymous said...

apotheke holland viagra viagra von innen homöopathisches viagra billiger als viagra viagra bericht günstiger viagra unterschied viagra cialis indisches viagra viagra vergleich kgr 100 viagra

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra tabletten viagra auf alkohol holland apotheke viagra viagra portal viagra wie teuer viagra benutzung viagra grippe viagra bei pulmonaler hypertonie viagra wie oft pro viagra

Anonymous said...

türkisch viagra viagra rezeptfrei holland viagra per nachname bestellen patentablauf viagra viagra original kaufen gibt es viagra in der apotheke grupa viagra viagra original erkennen viagra bestellen paypal kamagra pille 100mg viagra generika

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

pills viagra viagra generika günstig viagra aus deutschland bestellen viagra nebenwirkung ephedrin und viagra viagra wirkungsweise zoll viagra viagra für was viagra aus polen viagra dauerständer

Anonymous said...

viagra aus dem ausland viagra seriös viagra englisch sintrom viagra viagra partnerprogramm viagra tablette teilen pfizer labs viagra viagra in den niederlanden kaufen viagra hypertonie preis von viagra

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra joke bestellung von viagra besser als viagra rezeptpflicht viagra viagra richtig anwenden viagra geschichte viagra ablaufdatum vergleich levitra viagra cialis viagra forum bestellen viagra alter

Anonymous said...

verwendung von viagra indien viagra viagra todesfälle ägyptische viagra wann nehme ich viagra ein viagra wirkt nach holland apotheke viagra viagra versand viagra aus indien köpa viagra

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra betablocker viagra filmtabletten was bewirkt viagra viagra wann einnehmen viagra folgen norvasc viagra interaction dr. viagra viagra rezeptfrei in deutschland viagra für junge viagra wirkung wie lange

Anonymous said...

viagra gedicht viagra vectra viagra richtig einnehmen viagra im alter viagra frei erhältlich viagra anwendung rezept für viagra viagra in österreich viagra versagt viagra schädlich

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra joke viagra geschichte viagra packungsgrößen türkisches viagra medikament viagra viagra ejakulation viagra und poppers viagra generika kaufen viagra kaufen ohne rezept viagra bergsteigen

Anonymous said...

viagra at spam mail viagra dogal viagra viagra brasilien viagra kokain viagra aus china viagra rezeptfrei in deutschland kaufen viagra wie lange haltbar max viagra vorhofflimmern viagra

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

witze viagra viagra online preis viagra oder levitra viagra kauf online viagra billig cialis viagra levitra falsches viagra pumps und viagra viagra bei gesunden männern bestandteile von viagra

Anonymous said...

wirkungsweise viagra viagra 100 dosierung viagra wie teuer viagra in den usa kaufen viagra und hoher blutdruck berichte viagra viagra schneller versand discovery viagra gegenteil viagra apotheke niederlande viagra

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra aus england spam mail viagra viagra bestelle canada pharmacy viagra viagra 100 dosierung viagra verkaufen besser als viagra vergleich viagra viagra etkisi viagra at

Anonymous said...

costa rica viagra revatio viagra general motors viagra viagra bezugsquelle viagra pille viagra keine wirkung rezeptfrei viagra kaufen viagra nasenspray viagra kopfschmerzen viagra originalverpackung

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra nachwirkungen l-arginin viagra günstiges viagra sex auf viagra viagra in türkei viagra aus belgien viagra anwenden viagra wirkung wie lange viva viagra fox viagra

Anonymous said...

viagra bestellen per nachnahme viagra kaufen online viagra niederlande sex mit viagra viagra brasilien viagra per nachname bestellen apotheke niederlande viagra vorzeitiger samenerguss viagra spanische viagra levitra viagra cialis vergleich

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra pzn legal viagra kaufen viagra preis apotheke viagra kupic potenz viagra viagra oder ähnliches ohne rezept viagra in der schweiz kaufen viagra aus der schweiz viagra n1 ägyptische viagra

Anonymous said...

bayan viagra viagra selbst machen viagra online kaufen preise für viagra auswirkungen von viagra viagra schweiz viagra linz viagra natürlich funktion von viagra was bewirkt viagra

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra usa kaufen viagra rezept wo kann ich viagra kaufen viagra gebrauchsanweisung viagra bestelle ähnliches mittel wie viagra viagra halbwertszeit viagra generika forum viagra für windows discovery viagra

Anonymous said...

viagra internetapotheke viagra per lastschrift cialis oder viagra was ist besser viagra sport online viagra kaufen koktel viagra viagra stärke viagra brasilien viagra 100mg preis viagra dänemark

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

statt viagra viagra und blutdruck spc viagra viagra wie oft viagra in holland kaufen lungenhochdruck viagra gegenteil viagra viagra oder cialis natürlicher viagra ersatz viagra wirksamkeit

Anonymous said...

viagra in der schweiz viagra und nebenwirkungen viagra tipps online viagra und cialis kaufen viagra de wirkdauer viagra viagra absetzen viagra bestellung viagra indisch günstigste viagra

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

preis viagra viagra herzinfarkt viagra bestellen preisvergleich viagra rezeptfrei online kaufen viagra fakes max raabe viagra text viagra unverträglichkeit viagra packstation viagra in spanien viagra wieviel mg

Anonymous said...

legal viagra kaufen splitting viagra unterschied viagra cialis viagra in den usa kaufen viagra billig viagra selbst gemacht viagra usa kaufen viagra und arginin viagra gegenmittel revatio viagra

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra deutschland do czego jest viagra viagra gelb viagra in der apotheke kaufen viagra 100mg rezeptfrei viagra kaufen forum viagra online bestellen viagra wirkungszeit viagra selbst gemacht ibro berilo viagra

Anonymous said...

viagra in indien viagra online kaufen forum viagra grippe viagra apo viagra unverträglichkeit potent ohne viagra consumo de viagra wann nehme ich viagra ein viagra in deutschland bestellen viagra meinungen

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra wirkstoff wirkzeit viagra viagra vom arzt eu viagra viagra apotheke deutschland viagra woher generika für viagra viagra wirkmechanismus viagra schneller versand viagra günstig ohne rezept

Anonymous said...

viagra kur viagra für junge männer viagra in hamburg viagra haarausfall max raabe viagra günstigste viagra viagra ablaufdatum gegenteil viagra viagra erlebnisse viagra umsatz 2007

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra gegenmittel viagra hakkinda viagra usw viagra ohne rezept vergleich levitra viagra viagra pfizer preise rezeptpflichtig viagra viagra mit wasser einnehmen viagra aus belgien verwendung von viagra

Anonymous said...

preise von viagra viagra preis apotheke viagra frei bestellen echte viagra ipp viagra sofia viagra viagra wann viagra nach prostata op viagra englisch viagra münchen

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra 100 wirkung wirkungszeit viagra geschichte von viagra macht viagra impotent viagra online rezept uprima vs viagra preis von viagra alkohol und viagra preis viagra 100mg viagra tod

Anonymous said...

viagra ganz billig viagra zum bestellen viagra wirkung lässt nach beschreibung viagra gebrauchsanweisung viagra viagra sofort kaufen viagra hilft uprima vs viagra phyzer viagra gleiche wirkung wie viagra

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

wo bekomme ich viagra viagra in holland kaufen viagra wirkungszeit viagra generika rezeptfrei dove si compra il viagra gibt es viagra in der apotheke viagra gratisprobe viagra türkei viagra bestellen chinese viagra

Anonymous said...

nebenwirkung bei viagra scilla viagra viagra medikation splitting viagra viagra für was viagra verkaufen myspace viagra das erste mal viagra viagra im alter viagra sprüche

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra apotheke deutschland viagra kaufen köln was bewirkt viagra death by viagra viagra rezeptfrei ausland echtes viagra tablette viagra viagra dosierung natur viagra viagra gebrauchsanleitung

Anonymous said...

verkauf von viagra viagra dosierung viagra auf kassenrezept viagra ausprobiert viagra arten death by viagra why viagra aspirate viagra viagra aus usa viagra hakkinda

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra kaufen deutschland viagra studien viagra kaufen forum preis viagra 100mg silagra pille 100mg viagra generika viagra rezeptfrei schweiz viagra wirkt nicht mehr wenn viagra nicht hilft viagra generika indien viagra wirkungsweise

Anonymous said...

viagra frei viagra von pfitzer viagra apotheken viagra rezeptfrei niederlande viagra herzmedikament viagra funktioniert nicht viagra versand test viagra bezugsquelle viagra cialis rezeptfrei viagra versand rezeptfrei

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra in österreich kaufen china viagra viagra rezeptfrei in deutschland querschnittlähmung viagra blaue viagra hiv und viagra viagra sildenafil citrate viagra in brasilien wie wirkt viagra michi muzik viagra

Anonymous said...

aspirate viagra viagra oder cialis viagra doc morris vergleich viagra levitra pillen viagra pflanzliches viagra viagra wann king viagra viagra nachbau vergleich viagra

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

vergleich cialis viagra c20 viagra viagra und bluthochdruck viagra beipack viagra bei erkältung viagra pfizer kaufen natürliches viagra thailand viagra kaufen viagra wechselwirkungen viagra aus usa

Anonymous said...

viagra österreich rezeptfrei viagra russische fox viagra czy viagra uzaleznia viagra beipackzettel viagra bestellen.ch jetlag viagra kaufe viagra dhea viagra viagra kostet

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra apotheke rezeptfrei cialis oder viagra was ist besser viagra oder ähnliches ohne rezept viagra wechselwirkungen viagra haltbarkeit viagra droge besser als viagra viagra arten viagra bestellung viagra rezeptfrei holland

Anonymous said...

viagra mg viagra risiken und nebenwirkungen türkisches viagra viagra original rezeptfrei viagra online rezeptfrei bestellen spamassassin viagra viagra portal viagra frei bestellen viagra beihilfe viagra angebot

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

rezeptpflicht viagra viagra wirkungsdauer come il viagra generika viagra cialis myspace viagra viagra in italien kaufen unterschied cialis viagra original viagra rezeptfrei viagra billig kaufen viagra samenerguss

Anonymous said...

viagra cialis vergleich homöopathisches viagra viagra amerika viagra nasil kullanilir viagra rezeptfrei apotheke viagra ohne rezept auf rechnung neues viagra cialis oder viagra viagra pfizer nebenwirkungen viagra telefonisch bestellen

[url=http://www.turbo-slim.com/index.php?productID=11]viagra kaufen[/url]

viagra in italien kaufen viagra erektionsdauer potent ohne viagra wirkung der viagra pabst kauft viagra fabrik chinese viagra bayanlara viagra viagra entstehung sahte viagra viagra aus china

Anonymous said...

This particular workshop is focusing primarily on conversational analysis, but towards a focus on technology as well. http://www.verynorthface.com Dita Von Teese is known for her risqué burlesque outfits, and her wedding gown was far from conventional as well. ugg Skinny Jeans MenSkinny Jeans Men: Get The Best Jeans For Your Body Types Fashion is changing from time to time. north face canada If passed by the Congress, the Act undoubtedly would boost protection for designers. ugg At the very least it couldn't hurt to get away from New York.

Anonymous said...

After getting a positively obscene American Express bill, Karl had enough and cut off Josie. http://www.morenorthface.com Various online sites also offer information about the latest fashion trends and new styles.. ghds The main fabric of the dress is a navy metal blend fabric that I got at the Liday Baday Designer Fabric Showroom. http://www.softuggboots.com She definitely looks like the teenage maknae that she is, but she probably never recover the title from her fellow f(x) member Sulli!. north face sale Google's use of the DART cookie enables it to serve ads to your users based on their visit to your sites and other sites on the Internet.

Anonymous said...

Not only is this bad for your jewelry, but also can lead to skin rashes. north face jackets Sounds familiar, right? If so, then you may need to work a bit on how you store your jewelry. uggs canada A cut of the double breasted suits where a longer lapel line extends into the waist will help convey you as being taller than you may actually be, and if the cut is corret, it will also imply that you have a trim waist.. ugg boots uk For women who are extremely concerned about their hair style, a longer scarf would be optional. ghds There is no shame in beginning in a minor position that can lead to being the head of the department..

Anonymous said...

Members and the public may attend the public portion in which announcements will be made and questions taken from members and the public. http://www.verynorthface.com That equal to the number of the service active users those who bought, listed or sold something on eBay last year. http://www.softuggboots.com These jeans are loved by many women since those can show off their curves. ghd hair products So there is truly something for everyone in the Wedding Dress exhibit!. ghd hair straightener When you look around, you may see that Vera Bradley handbags are pretty well known.

Anonymous said...

peelvistiptug xaikalitag SomsBelmwem [url=http://uillumaror.com]iziananatt[/url] Fleemahevelay http://gusannghor.com Doffevete

Anonymous said...

towards police officers and were more able to resist peer pressure (De Jong, 1987; Clayton et al., 1991a). However, a meta-analysis of eight previous DARE evaluations found that the only significant outcome was an increased knowledge generic cialis generic cialis,cialis cialis, viagra cialis price,viagra online cialis price
http://genericcialispricegnf.com#cialis online http://cialisonlinepillsgkd.com#cialis pills http://genericviagraonlinejvrg.com#viagra online http://buyviagraonlinertvr.com#viagra

Anonymous said...

Controlled Prescription Drug Only vs. Poly-Substance Abusers ......................4 cialis generic cialis,cialis generic cialis, generic viagra generic cialis,viagra online cialis price
http://genericcialispricegnf.com#cialis http://cialisonlinepillsgkd.com#cialis online http://genericviagraonlinejvrg.com#viagra http://buyviagraonlinertvr.com#buy viagra

Anonymous said...

Mr. H, now our patient, indicated that he was first treated with Viagra, a pill to treat erectile dysfunction, also known as impotence, but that was not an effective ED treatment. He then mentioned that he was then treated with injection therapy at a clinic that advertised guaranteed results. This is an ED treatment where the patient injects a small amount of medication into the side of the penis using a very small needle. This was only partially effective as he did not achieve adequate rigidity. Upon further questioning, he said that he was not sure he was injecting himself correctly as he was never observed performing a self injection. In addition, he was not sure he ever tried the maximum dose. At the conclusion of the visit, Mr. H. decided to pursue injection therapy and not penile implants as his next step [to fix his erectile dysfunction.] He may not have an adequate result with injections, even using the correct technique at the maximum dose and then pursue an implant. Should he ultimately receive an implant, he will have that surgery knowing that he truly considered all alternatives, and will be confident that a penile implant is the best option for the treatment of his erectile dysfunction. generic cialis cialis,cialis pills generic cialis, viagra online cialis,buy viagra cialis price
http://genericcialispricegnf.com#cialis http://cialisonlinepillsgkd.com#cialis http://genericviagraonlinejvrg.com#generic viagra http://buyviagraonlinertvr.com#viagra online

Anonymous said...

II controlled substance that blocks the euphoric cialis price cialis,cialis online cialis price, viagra cialis,viagra cialis
http://genericcialispricegnf.com#cialis http://cialisonlinepillsgkd.com#cialis online http://genericviagraonlinejvrg.com#viagra http://buyviagraonlinertvr.com#buy viagra

Anonymous said...

with continued use or the need to take increasing cialis generic cialis,cialis cialis, viagra generic cialis,viagra online generic cialis
http://genericcialispricegnf.com#cialis http://cialisonlinepillsgkd.com#cialis pills http://genericviagraonlinejvrg.com#viagra http://buyviagraonlinertvr.com#viagra online

Anonymous said...

Double Dare: cialis price generic cialis,cialis cialis price, viagra cialis price,viagra online generic cialis
http://genericcialispricegnf.com#cialis http://cialisonlinepillsgkd.com#cialis online http://genericviagraonlinejvrg.com#viagra online http://buyviagraonlinertvr.com#viagra